Results 51 to 60 of about 8,908 (223)

Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]

Cardiovascular Drugs and Therapy, 2020
AbstractAgeing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction.
Emily Dookun, João F. Passos, Helen M. Arthur, Gavin D. Richardson   +3 more
openaire   +3 more sources

Senescence explains age- and obesity-related liver steatosis

Cell Stress, 2017
Cellular senescence, the irreversible loss of replicative potential of somatic cells, was first described in fibroblasts cultured in vitro by Leonard Hayflick more than 50 years ago.
Mikolaj Ogrodnik, Diana Jurk
doaj   +1 more source

Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression

Journal of Functional Biomaterials, 2022
Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang, Yulin Tseng, Keyu Chen, Xinglin Wang, Zebin Mao, Xuemin Li   +5 more
doaj   +1 more source

Effect of Senolytic to alleviating Osteoporosis in Mice induced by Retinoic Acid [PDF]

E3S Web of Conferences, 2020
Senolytic is a potential new anti-aging drug, and it is worth exploring whether it has an inhibitory effect on osteoporosis. Osteoporosis models in mice were established by gavage of retinoic acid(RA), and Senolytic drugs (dasatinib and quercetin) were ...
Liu Jia, Xiao Yazhe, Xie Jing, He Lian
doaj   +1 more source

Senolytics in the treatment of diabetic retinopathy

Frontiers in Pharmacology, 2022
Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness. The pathogenic mechanism of DR is complex; emerging studies suggest that premature senescence of retinal cells and subsequent secretion of ...
Hassan, Jannah Waled, Bhatwadekar, Ashay D.   +1 more
openaire   +4 more sources

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Molecular Metabolism
Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the role of senescence in obesity-induced metabolic disorders and in cardiac dysfunction is not yet clear ...
Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz   +10 more
doaj   +1 more source

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium [PDF]

, 2017
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs ...
Acosta, Aird, Al-Sabbagh, Barros, Bradford, Childs, Chowdhury, de Keizer, de Ziegler, Demidenko, Diep, Dimri, Drury, Erlebacher, Evans, Funayama, Gellersen, Groll, Hanna, Hapangama, Iannello, Krizhanovsky, Laws, Lucas, Lucas, Marçais, Matjusaitis, Mosteiro, Murakami, Muñoz-Espín, Paria, Park, Pfaffl, Pohnke, Rajagopalan, Ritschka, Ruifrok, Sadaie, Saeed, Sagiv, Sagiv, Salker, Smith, Takano, Team, van Deursen, Venables, Xiong, Yuan, Zhang, Zhu, Zhu   +51 more
core   +2 more sources

The Clinical Potential of Senolytic Drugs [PDF]

Journal of the American Geriatrics Society, 2017
Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland, Tamara, Tchkonia, Yi, Zhu, Laura J, Niedernhofer, Paul D, Robbins   +4 more
openaire   +2 more sources

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Frontiers in Cell and Developmental Biology, 2020
Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but chronic senescence, as in aging, can contribute to the development of age-related tissue dysfunction and disease.
Anuj K. Sharma, Rachel L. Roberts, Reginald D. Benson, Jessica L. Pierce, Kanglun Yu, Mark W. Hamrick, Meghan E. McGee-Lawrence, Meghan E. McGee-Lawrence   +7 more
doaj   +1 more source

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target. [PDF]

Aging Cell
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Zhang M, Hu Z, Piao S, Song Y, Jia Y, Liu J, Zhao N, Liu A, Fu S, Sun W, Xu H, Yang Y, Gygi SP, Zhou C.   +13 more
europepmc   +2 more sources