Results 61 to 70 of about 8,908 (223)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Frontiers in Pharmacology, 2018
Cellular senescence is identified by a living cell in irreversible and persistent cell cycle arrest in response to various cellular stresses. Senescent cells secrete senescence-associated secretory phenotype factors that can amplify cellular senescence ...
Mengqian Li, Liting You, Jianxin Xue, You Lu   +3 more
doaj   +1 more source

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation [PDF]

, 2018
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage
Argani, Ashworth, Ashworth, Bacchetti, Bacchetti, Bai, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Bao, Burkle, Chang, Curtin, Dahm-Daphi, Dantzer, Dantzer, Dantzer, de Bono, de Lange, de Lange, de Lange, de Lange, De Marzo, DePinho, DePinho, Fegan, Fegan, Helleday, Helleday, Hendrickson, Iliakis, Jackson, Jackson, Karlseder, Lehtio, Lieber, Liu, Moroni, Ouellette, Pellat-Deceunynck, Pellicciari, Piwnica-Worms, Pommier, Pommier, Reddel, Robbins, Rottenberg, Salzer, Schuler, Schuler, Sfeir, Smith, Sugano, Weinberg, Wynford-Thomas, Zupi   +60 more
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells

Life
This study investigated the effects of chelidonic acid (CA) on hydrogen peroxide (H2O2) induced cellular senescence in human skin fibroblast cells (BJ).
Burcu Turkoglu, Banu Mansuroglu
doaj   +1 more source

DNA damage: A main determinant of vascular aging [PDF]

, 2016
Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of ...
Bautista-Niño, P.K. (Paula), Danser, A.H.J. (Jan), Portilla-Fernandez, E. (Eliana), Roks, A.J.M. (Anton), Vaughan, D.E. (Douglas E.)   +4 more
core   +2 more sources

Sorafenib, Rapamycin, and Venetoclax Attenuate Doxorubicin-Induced Senescence and Promote Apoptosis in HCT116 Cells [PDF]

, 2021
Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity.
Alhazzani, Khalid, Alhoshani, Ali R., Almutairi, Mashal M., Alohaydib, Munirah, Alotiabi, Moureq R., As Sobeai, Homood M., Gewirtz, David A., Saleh, Tareq   +7 more
core   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice

Frontiers in Medicine
IntroductionChronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Jonathan R. Baker, Leah Daly, Shyreen Hassibi, Genki Kimura, Yuki Nishimoto, Yasuo Kizawa, Kazuhiro Ito   +6 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source