Results 71 to 80 of about 8,908 (223)

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

Frontiers in Pharmacology, 2023
Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong, Li Ping Wong, Haridah Alias, Kit Mun Tan, Pooi Fong Wong, Dharmani Devi Murugan, Zhijian Hu, Yulan Lin   +7 more
doaj   +1 more source

Cellular Senescence as the Causal Nexus of Aging [PDF]

, 2016
In this paper we present cellular senescence as the ultimate driver of the aging process, as a “causal nexus” that bridges microscopic subcellular damage with the phenotypic, macroscopic effect of aging.
Antonei B. Csoka, Evgeny O. Makarev, Naina Bhatia-Dey, Riya R. Kanherkar, Susan E. Stair   +4 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Oxidation products of 5-methyl cytosine are decreased in senescent cells and tissues of progeroid mice [PDF]

, 2018
5-Hydroxymethylcytosine and 5-formylcytosine are stable DNA base modifications generated from 5-methylcytosine by the ten-eleven translocation protein family that function as epigenetic markers. 5-Hydroxymethyluracil may also be generated from thymine by
Czerwińska, Jolanta, Foksinski, Marek, Gackowski, Daniel, Gregg, Siobhán Q., Niedernhofer, Laura J., Oliński, Ryszard, St. Croix, Claudette M., Starczak, Marta, Szpila, Anna, Tudek, Barbara, Tupalska, Agnieszka, Yousefzadeh, Matt J., Zarakowska, Ewelina   +12 more
core   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Frontiers in Cell and Developmental Biology, 2023
Cellular senescence represents an irreversible state of cell cycle arrest induced by various stimuli strongly associated with aging and several chronic ailments.
Huantong Zhang, Han Zhou, Xin Shen, Xingchen Lin, Yuke Zhang, Yiyi Sun, Yi Zhou, Lei Zhang, Lei Zhang, Dayong Zhang   +9 more
doaj   +1 more source

Oncogenic senescence: a multi-functional perspective. [PDF]

, 2017
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma, Baker, Darren J, Campisi, Judith, Hildesheim, Jeffrey, van Deursen, Jan M   +4 more
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics

Advanced Healthcare Materials
AbstractCellular senescence is a significant risk factor for aging and age‐related diseases (ARD). The canonical senolytics Dasatinib and Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses a challenge in achieving optimal outcomes.
Hairui Zhang, Xiaoling Xu, Xin Shou, Wucan Liao, Chengkang Jin, Changjiang Chen, Chen Zhang, Wenhua Gao, Junfeng Zhang, Weihong Ge, Liyun Shi   +10 more
openaire   +2 more sources

Senopathies—Diseases Associated with Cellular Senescence

Biomolecules, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak, Markus Schosserer, Johannes Grillari   +2 more
doaj   +1 more source