Results 81 to 90 of about 8,908 (223)
New phytochemicals as potential human anti-aging compounds: reality, promise, and challenges [PDF]
, 2017 Aging is an inevitable process influenced by genetic, lifestyle, and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to
Bracht, Adelar +5 more
core +1 more source
Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss
iMetaMed, EarlyView.As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu +6 more
wiley +1 more source
Senescent cells: New target for an old treatment?
Molecular & Cellular Oncology, 2017 Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation.
Marco Demaria
doaj +1 more source
Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
Cells, 2020 Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution.
Francisco Triana-Martínez +2 more
doaj +1 more source
eLife, 2022 Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence progression via bystander effects are significant causes of this premature ageing phenotype ...
Edward Fielder +12 more
doaj +1 more source
Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease
, 2017 Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases.
Barnes, PJ, Birch, J, Passos, JF
core +1 more source
Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6. [PDF]
, 2017 Senescent cells may exert detrimental effect on microenvironment through the secretion of soluble factors and the release of extracellular vesicles, such as microparticles, key actors in ageing and cardiovascular diseases.
Bachelier, R. +12 more
core +3 more sources
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan [PDF]
Innovation in Aging, 2020 Abstract Cellular senescence is a cell fate decision that is made by many mammalian cell types in response to damage, stress or certain physiological signals. Senescent cells arrest proliferation, essentially permanently, and develop a complex multi-component senescence-associated secretory phenotype (SASP).
openaire +1 more source
Anti-aging: senolytics or gerostatics (unconventional view) [PDF]
Oncotarget, 2021 Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit oncogene-addiction and to combine drugs to achieve selectivity.
openaire +2 more sources