Results 191 to 200 of about 6,287 (219)

Differential responses to the combination of navitoclax and venetoclax with doxorubicin in murine models of triple negative breast cancer. [PDF]

Front Cell Dev Biol
As Sobeai HM, Alanazi AM, Alotaibi F, Alhoshani A, Alhazzani K, Almutairi MM, Almudimeegh S, Al-Ramadi BK, Chakraborty E, Saleh T, Gewirtz DA, Harada H, Alotaibi MR.   +12 more
europepmc   +1 more source

Immunosenescence and inflammaging in Parkinson's disease: mechanisms and therapeutic prospects. [PDF]

Front Immunol
Yan R, Feng H, Zhang J.
europepmc   +1 more source

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction. [PDF]

Cells
De Luca F, Camporeale V, Leccese G, Cuttano R, Troise D, Infante B, Stallone G, Netti GS, Ranieri E.   +8 more
europepmc   +1 more source

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Obesity, Senescence, and Senolytics

2021
Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs.
Selim, Chaib, Tamara, Tchkonia, James L, Kirkland   +2 more
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Chemo-Senolytic Therapeutic Potential against Angiosarcoma

Journal of Investigative Dermatology, 2023
AbstractAngiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, one of the taxanes (genotoxic drugs), although it has a limited effect due to chemoresistance for prolonged treatment.
Xuebing Wang, Claire Yik-Lok Chung, Ai Yoshioka, Shinya Hashimoto, Haruki Jimbo, Hideki Tanizawa, Shinya Ohta, Takeshi Fukumoto, Ken-ichi Noma   +8 more
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The potential of Senolytics in transplantation

Mechanisms of Ageing and Development, 2021
Older organs provide a substantial unrealized potential with the capacity to close the gap between demand and supply in organ transplantation. The potential of senolytics in improving age-related conditions has been shown in various experimental studies and early clinical trials. Those encouraging data may also be of relevance for transplantation.
Tomohisa Matsunaga, Jasper Iske, Andreas Schroeter, Haruhito Azuma, Hao Zhou, Stefan G. Tullius   +5 more
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Senolytic Drugs: Implications for Clinical Practice

Advances in Gerontology, 2023
The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline of cell proliferation and resilience are highlighted in vitro studies, as
A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko   +6 more
openaire   +1 more source