Results 121 to 130 of about 1,457 (176)
Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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Revolutionizing Aging: The Dawn of Longevity Medicine and Lifespan Extension [PDF]
Ageing, conventionally measured as an inevitable biological process, is one of the major areas of leading-edge scientific research. Nowadays, the field of senolytics, telomere extension and other cellular rejuvenation techniques intended at tackling ...
Irfan, Asma
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Bioactive MaterialsOsteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP ...
Wenan Peng +9 more
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Advanced ScienceThe pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration of natural products endowed with inherent medicinal properties.
Jiqun Wang +11 more
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Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity
Frontiers in Bioscience-LandmarkAgeing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the ...
Afsar U. Ahmed
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Insights from Preclinical Data [PDF]
Funding Information: National Funds via FCT (Foundation for Science and Technology) through the Strategic Projects UIDB/04539/2020 and UIDP/04539/2020 (CIBB) and the Exploratory Project PATCH (022.05810.PTDC) and BPI/La Caixa Foundation and FCT under the
Alves-Silva, Jorge +3 more
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MetabolitesChronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
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Cellular senescence and wound healing in aged and diabetic skin [PDF]
Cellular senescence is a biological mechanism that prevents abnormal cell proliferation during tissue repair, and it is often accompanied by the secretion of various factors, such as cytokines and chemokines, known as the senescence-associated secretory ...
Arisa Kita +4 more
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Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
AbstractCellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and
Hongwei Zhang +7 more
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Proceedings of the National Academy of SciencesIncreased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors.
Yidan Liu +13 more
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