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Senotherapeutics: Milestones, innovations, and future prospects
Gerontological practice has evolved over the decades in response to various diseases, comorbidities, and demographic factors. The many subfields that have emerged from our advancement include the study of biomedical gerontology. Geropharmacology, which began to be recognized as a distinct subfield in the latter part of the 20th century, is the study ofAtasever, Erdem +2 more
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Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
2023Neurodegenerative diseases are a group of age-related disorders characterized by a chronic and progressive loss of function and/or structure of synapses, neurons, and glial cells. The etiopathogenesis of neurodegenerative diseases is characterized by a complex network of intricately intertwined pathophysiological processes that are still not fully ...
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Senotherapeutic approach to age-related endocrine diseases
Senescent cells progressively accumulate in the endocrine glands and their target tissue during the biological aging process. Senescence leads to hormonal imbalances contributing to various age-related endocrine diseases (AREDs). Cellular senescence, characterized by irreversible cell-cycle arrest, becomes more prevalent in advanced age, and the ...Turgut, Seydanur, Andican, Gülnur
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Natural Product-Derived Senotherapeutics: Extraction and Biological Evaluation Techniques
Selective targeting of senescent cells has been thus far considered a widespread preventive strategy, as well as a main or adjuvant therapy for age-associated diseases, fueling the research on the discovery of senotherapeutics (i.e., senolytic or senomorphic compounds).Harris, Pratsinis +5 more
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Senotherapeutics: Experimental therapy of cellular senescence
2021Jamie N. Justice +2 more
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NEW SENOTHERAPEUTIC PEPTIDES FOR OSTEOARTHRITIS TREATMENT
Osteoarthritis and CartilageIñaki López-Díaz +5 more
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