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Marine phycocompound screening reveals a potential source of novel senotherapeutics
Journal of Biomolecular Structure and Dynamics, 2021Cells undergo a controlled and systematic cycle of growth, replication and death. However, the integrity of this process gradually declines, leading to accumulation of senescent cells, a major hallmark of biological ageing. Dietary algae, particularly marine algae, have been long reported to exert anti-ageing benefits as cosmeceuticals and ...
Rahagir Salekeen +6 more
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Stem cell-derived extracellular vesicles as senotherapeutics
Ageing Research ReviewsCellular senescence (CS) is recognized as one of the hallmarks of aging, and an important player in a variety of age-related pathologies. Accumulation of senescent cells can promote a pro-inflammatory and pro-cancerogenic microenvironment. Among potential senotherapeutics are extracellular vesicles (EVs) (40-1000 nm), including exosomes (40-150 nm ...
Alex Braiman +2 more
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Cellular parabioisis as a senotherapeutic approach
Beyond cell death and differentiation, cell senescence is profoundly influenced by the social nature of cells, which is intricately linked to cell communication as a fundamental aspect of biological systems shaping both individual and collective cellular behaviors.Sencan, Sevide, Onaran, Ilhan
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Senotherapeutics: Milestones, innovations, and future prospects
Gerontological practice has evolved over the decades in response to various diseases, comorbidities, and demographic factors. The many subfields that have emerged from our advancement include the study of biomedical gerontology. Geropharmacology, which began to be recognized as a distinct subfield in the latter part of the 20th century, is the study ofAtasever, Erdem +2 more
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Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
2023Neurodegenerative diseases are a group of age-related disorders characterized by a chronic and progressive loss of function and/or structure of synapses, neurons, and glial cells. The etiopathogenesis of neurodegenerative diseases is characterized by a complex network of intricately intertwined pathophysiological processes that are still not fully ...
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Senotherapeutic approach to age-related endocrine diseases
Senescent cells progressively accumulate in the endocrine glands and their target tissue during the biological aging process. Senescence leads to hormonal imbalances contributing to various age-related endocrine diseases (AREDs). Cellular senescence, characterized by irreversible cell-cycle arrest, becomes more prevalent in advanced age, and the ...Turgut, Seydanur, Andican, Gülnur
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Natural Product-Derived Senotherapeutics: Extraction and Biological Evaluation Techniques
Selective targeting of senescent cells has been thus far considered a widespread preventive strategy, as well as a main or adjuvant therapy for age-associated diseases, fueling the research on the discovery of senotherapeutics (i.e., senolytic or senomorphic compounds).Harris, Pratsinis +5 more
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