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The interconnections between gerontogen, aging, and senotherapy
Journal of Applied Pharmaceutical ScienceAging causes various degenerative diseases in the older adult population. Senescence, a state of permanent cell-cycle arrest accompanied by the production of various pro-inflammatory factors known as senescence-associated secretory phenotype (SASP), is ...
R. Rahma, A. J. Barinda
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Proteolysis targeting chimeras as senolytics: An emerging senotherapy for combating aging.
The Journal of Pharmacology and Experimental TherapeuticsCellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives aging-related phenotypes.
Alexis B. Cruickshank-Taylor +4 more
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Senotherapy for lung diseases.
Advances in Pharmacology, 2023Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
P. Barnes
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Targeting normal and cancer senescent cells as a strategy of senotherapy.
Ageing Research Reviews, 2019Senotherapy is an antiaging strategy. It refers to selective killing of senescent cells by senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or alleviating the secretory phenotype (SASP) of senescent cells.
E. Sikora +2 more
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SpringerBriefs in Modern Perspectives on Disability Research
Gabriel Bennett
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Gabriel Bennett
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Lineage-guided senescence insights unlock precision senotherapy
Aging ResearchZiqi Kang +3 more
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, 2020
Cellular senescence is a stress and repair response that protects us from cancer and contributes to tissue homeostasis by inducing a stable cell cycle arrest and imposing a secretory phenotype. Senescent cells are held in check to avoid their aberrant proliferation while at the same time they serve as new signaling nodes to orchestrate tissue repair ...
Pilar Picallos-Rabina +4 more
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Cellular senescence is a stress and repair response that protects us from cancer and contributes to tissue homeostasis by inducing a stable cell cycle arrest and imposing a secretory phenotype. Senescent cells are held in check to avoid their aberrant proliferation while at the same time they serve as new signaling nodes to orchestrate tissue repair ...
Pilar Picallos-Rabina +4 more
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Senotherapy: growing old and staying young?
Pflügers Archiv - European Journal of Physiology, 2017Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair.
R. Schmitt
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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Pharmacological Reviews, 2023An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to ...
Lucas, Vasco +2 more
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Senotherapies: A novel strategy for synergistic anti-tumor therapy
Drug Discovery Today, 2022Cellular senescence was initially considered an effective antitumor mechanism, and senescence-induced therapy has previously been regarded as an efficient treatment. However, increasing studies have discovered that persistent senescent cells (SNCs) might have unanticipated negative repercussions for antitumor treatment.
Xuxin, Qi, Li, Jiang, Ji, Cao
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