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Targeting normal and cancer senescent cells as a strategy of senotherapy
Ageing Research Reviews, 2019Senotherapy is an antiageing strategy. It refers to selective killing of senescent cells by senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or alleviating the secretory phenotype (SASP) of senescent cells. As senescent cells accumulate with age and are considered to be at the root of age-related disorders ...
Ewa Sikora +2 more
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Senotherapy, cancer, and aging
Journal of Geriatric OncologyWe aimed to highlight the effects of senotherapy on the prevention and treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent cells. These cells express the senescence-associated secretory phenotype (SASP). With production of inflammatory cytokines, growth factors, and different type of proteases, the SASP is ...
Balducci, L. +2 more
exaly +5 more sources
2023
Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
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Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
openaire +2 more sources
2020
Cellular senescence is a stress and repair response that protects us from cancer and contributes to tissue homeostasis by inducing a stable cell cycle arrest and imposing a secretory phenotype. Senescent cells are held in check to avoid their aberrant proliferation while at the same time they serve as new signaling nodes to orchestrate tissue repair ...
Pilar Picallos-Rabina +4 more
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Cellular senescence is a stress and repair response that protects us from cancer and contributes to tissue homeostasis by inducing a stable cell cycle arrest and imposing a secretory phenotype. Senescent cells are held in check to avoid their aberrant proliferation while at the same time they serve as new signaling nodes to orchestrate tissue repair ...
Pilar Picallos-Rabina +4 more
openaire +1 more source
[Senotherapy: Advances and new clinical perspectives].
Medecine sciences : M/S, 2021Cellular senescence has been now shown to be at the root of many degenerative processes that characterize ageing. Thus, in addition to an irreversible proliferative arrest following various stresses or inappropriate stimuli, cellular senescence leads to genetic, epigenetic, metabolic, structural and functional adaptations of the cell.
Damien, Veret, Jean-Marc, Brondello
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2018
Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
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Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
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Senotherapy for attenuation of cellular senescence in aging and organ implantation
Journal of Industrial and Engineering Chemistry, 2018Abstract Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP).
Dong Yun Lee
exaly +2 more sources
Senotherapy: Implications for Transplantation
TransplantationCellular senescence has been identified as a potential driver of age-associated loss of organ function and as a mediator of age-related disease. Novel strategies in targeting senescent cells have shown promise in several organ systems to counteract functional decline, chronic inflammation, and age-dependent loss of repair capacity.
Martin Jaros, Anette Melk
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Senotherapy: A New Horizon for COPD Therapy.
Chest, 2021There is increasing evidence that COPD is a disease of accelerated lung aging, with the accumulation of senescent cells that lose their ability to repair and secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), which mimic the profile of inflammatory mediators secreted in COPD.
Jonathan R, Baker +2 more
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Apoptosis-coupled senescence causes cancer cell senotherapy
2023AbstractAlthough new generations of anti-cancer modalities have been accumulated involving immuno-oncology cancers remain prevailing. This implies the current understanding of cancer cell biology is far from satisfactory. Curation of cancers is extremely rare.
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