Results 11 to 20 of about 1,424 (160)

Serial femtosecond crystallography: the first five years [PDF]

IUCrJ, 2015
Protein crystallography using synchrotron radiation sources has had a tremendous impact on biology, having yielded the structures of thousands of proteins and given detailed insight into their mechanisms.
Ilme Schlichting
doaj   +4 more sources

Experimental phasing of serial femtosecond crystallography data [PDF]

IUCrJ, 2017
A synopsis of and prospects for de novo phasing using diffraction data collected at X-ray free-electron lasers are given.
Ilme Schlichting
doaj   +4 more sources

A novel inert crystal delivery medium for serial femtosecond crystallography [PDF]

IUCrJ, 2015
Serial femtosecond crystallography (SFX) has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins.
Chelsie E. Conrad, Shibom Basu, Daniel James, Dingjie Wang, Alexander Schaffer, Shatabdi Roy-Chowdhury, Nadia A. Zatsepin, Andrew Aquila, Jesse Coe, Cornelius Gati, Mark S. Hunter, Jason E. Koglin, Christopher Kupitz, Garrett Nelson, Ganesh Subramanian, Thomas A. White, Yun Zhao, James Zook, Sébastien Boutet, Vadim Cherezov, John C. H. Spence, Raimund Fromme, Uwe Weierstall, Petra Fromme   +23 more
doaj   +5 more sources

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase [PDF]

IUCrJ, 2015
Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) enables high-resolution protein structure determination using micrometre-sized crystals at room temperature with minimal effects from radiation damage.
Raimund Fromme, Andrii Ishchenko, Markus Metz, Shatabdi Roy Chowdhury, Shibom Basu, Sébastien Boutet, Petra Fromme, Thomas A. White, Anton Barty, John C. H. Spence, Uwe Weierstall, Wei Liu, Vadim Cherezov   +12 more
doaj   +5 more sources

Possibilities for serial femtosecond crystallography sample delivery at future light sources [PDF]

Structural Dynamics, 2015
Serial femtosecond crystallography (SFX) uses X-ray pulses from free-electron laser (FEL) sources that can outrun radiation damage and thereby overcome long-standing limits in the structure determination of macromolecular crystals.
L. M. G. Chavas, L. Gumprecht, H. N. Chapman   +2 more
doaj   +4 more sources

Time-resolved serial femtosecond crystallography at the European XFEL. [PDF]

Nat Methods, 2020
Published by Nature Publishing Group, London [u.a.]
Pandey S, Bean R, Sato T, Poudyal I, Bielecki J, Cruz Villarreal J, Yefanov O, Mariani V, White TA, Kupitz C, Hunter M, Abdellatif MH, Bajt S, Bondar V, Echelmeier A, Doppler D, Emons M, Frank M, Fromme R, Gevorkov Y, Giovanetti G, Jiang M, Kim D, Kim Y, Kirkwood H, Klimovskaia A, Knoska J, Koua FHM, Letrun R, Lisova S, Maia L, Mazalova V, Meza D, Michelat T, Ourmazd A, Palmer G, Ramilli M, Schubert R, Schwander P, Silenzi A, Sztuk-Dambietz J, Tolstikova A, Chapman HN, Ros A, Barty A, Fromme P, Mancuso AP, Schmidt M.   +47 more
europepmc   +7 more sources

Chemical crystallography by serial femtosecond X-ray diffraction [PDF]

Nature, 2022
AbstractInorganic–organic hybrid materials represent a large share of newly reported structures, owing to their simple synthetic routes and customizable properties1. This proliferation has led to a characterization bottleneck: many hybrid materials are obligate microcrystals with low symmetry and severe radiation sensitivity, interfering with the ...
Elyse A. Schriber, Daniel W. Paley, Robert Bolotovsky, Daniel J. Rosenberg, Raymond G. Sierra, Andrew Aquila, Derek Mendez, Frédéric Poitevin, Johannes P. Blaschke, Asmit Bhowmick, Ryan P. Kelly, Mark Hunter, Brandon Hayes, Derek C. Popple, Matthew Yeung, Carina Pareja-Rivera, Stella Lisova, Kensuke Tono, Michihiro Sugahara, Shigeki Owada, Tevye Kuykendall, Kaiyuan Yao, P. James Schuck, Diego Solis-Ibarra, Nicholas K. Sauter, Aaron S. Brewster, J. Nathan Hohman   +26 more
openaire   +4 more sources

Serial X-ray Crystallography

Crystals, 2022
Serial crystallography (SX) is an emerging technique to determine macromolecules at room temperature. SX with a pump–probe experiment provides the time-resolved dynamics of target molecules.
Ki Hyun Nam
doaj   +1 more source

Polyacrylamide injection matrix for serial femtosecond crystallography. [PDF]

Sci Rep, 2019
AbstractSerial femtosecond crystallography (SFX) provides opportunities to observe the dynamics of macromolecules without causing radiation damage at room temperature. Although SFX provides a biologically more reliable crystal structure than provided by the existing synchrotron sources, there are limitations due to the consumption of many crystal ...
Park J, Park S, Kim J, Park G, Cho Y, Nam KH.   +5 more
europepmc   +4 more sources

A Bright Future for Serial Femtosecond Crystallography with XFELs. [PDF]

Trends Biochem Sci, 2017
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged serial femtosecond (fs) crystallography (SFX) approach using XFEL radiation overcomes some of the biggest hurdles of ...
Johansson LC, Stauch B, Ishchenko A, Cherezov V.   +3 more
europepmc   +4 more sources