Results 31 to 40 of about 190,299 (260)

Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells

Toxins, 2022
Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs in aquatic environments worldwide. It is known for its delayed effects in animals and humans such as inhibition of protein synthesis or genotoxicity.
Sabine Ziesemer, Susann Meyer, Julia Edelmann, Janita Vennmann, Celine Gudra, Denise Arndt, Marcus Effenberg, Olla Hayas, Aref Hayas, Johanna Sophia Thomassen, Barbara Kubickova, Dierk-Christoph Pöther, Jan-Peter Hildebrandt   +12 more
doaj   +1 more source

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression.

Journal of Medicinal Chemistry, 2021
Hepatocyte growth factor (HGF), the ligand for the MET receptor tyrosine kinase, is a tumor-promoting factor that is abundant in the tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more of the serine endopeptidases matriptase,
V. Damalanka, Jorine Voss, Matthew W. Mahoney, Tina M Primeau, Shunqiang Li, L. Klampfer, J. Janetka   +6 more
semanticscholar   +1 more source

Intersexual Differences in the Gene Expression of Phoneutria depilata (Araneae, Ctenidae) Toxins Revealed by Venom Gland Transcriptome Analyses

Toxins, 2023
The wandering spider, Phoneutria depilata, is one of Colombia’s most active nocturnal arthropod predators of vertebrates and invertebrates. Its venom has been a relevant subject of study in the last two decades.
Diego Sierra Ramírez, Juan F. Alzate, Yuri Simone, Arie van der Meijden, Giovany Guevara, Lida Marcela Franco Pérez, Julio César González-Gómez, Carlos F. Prada Quiroga   +7 more
doaj   +1 more source

Plant-Programmed Cell Death-Associated Genes Participation in Pinus sylvestris L. Trunk Tissue Formation

Plants, 2022
Molecular genetic markers of various PCD (programmed cell death) variants during xylo- and phloemogenesis have been identified for the first time in Scots pine under lingonberry pine forest conditions in Northwest Russia (middle taiga subzone).
Yulia L. Moshchenskaya, Natalia A. Galibina, Kseniya M. Nikerova, Tatiana V. Tarelkina, Maksim A. Korzhenevsky, Irina N. Sofronova, Maria A. Ershova, Ludmila I. Semenova   +7 more
doaj   +1 more source

Filling the Gaps to Solve the Extensin Puzzle [PDF]

, 2018
Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia, Bringas, Mauro, Capece, Luciana, Estevez, Jose Manuel, Marzol, Eliana, Rodríguez Garcia, Diana Rosa, Sede, Ana Rocío   +6 more
core   +1 more source

Characterisation of proteins in excretory/secretory products collected from salmon lice, Lepeophtheirus salmonis

Parasites & Vectors, 2018
Background The salmon louse, Lepeophtheirus salmonis, is an ectoparasitic copepod which feeds on the mucus, skin and blood of salmonid fish species. The parasite can persist on the surface of the fish without any effective control being exerted by the ...
Scott Hamilton, Kevin McLean, Sean J. Monaghan, Carol McNair, Neil F. Inglis, Hazel McDonald, Sandra Adams, Randolph Richards, William Roy, Patrick Smith, James Bron, Alasdair J. Nisbet, David Knox   +12 more
doaj   +1 more source

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]

PLoS ONE, 2013
Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostrov   +9 more
doaj   +1 more source

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Molecules, 2018
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield.
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht   +11 more
doaj   +1 more source

Action of Serine Carboxypeptidases on Endopeptidase Substrates, N-Acyldipeptideamides [PDF]

Bulletin of the Chemical Society of Japan, 1987
Abstract Action patterns of two serine carboxypeptidases, one from yeast (Y) and the other from wheat bran (W), on N-[3-(2-furyl)acryloyl]-(Fua-) dipeptideamide substrates were examined by HPLC and amino acid analysis. In the reaction of the wheat enzyme the substrates were hydrolyzed to Fua-amino acid and no sufficient amount of Fua ...
Shigeru Kunugi, Kazuo Tanabe, Kouji Yamashita, Mitsuhiro Fukuda   +3 more
openaire   +1 more source

The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape

BMC Genomics, 2017
Background The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before ...
Shengzhang Dong, Susanta K. Behura, Alexander W. E. Franz   +2 more
doaj   +1 more source