Results 1 to 10 of about 9,573 (184)

Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in Acinetobacter baumannii [PDF]

Metabolites
Background/Objectives: Acinetobacter baumannii is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed.
Mansour S. Alturki, Abdulaziz H. Al Khzem, Mohamed S. Gomaa, Nada Tawfeeq, Marwah H. Alhamadah, Futun M. Alshehri, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o, Khaled A. G. Ayil, Abdulaziz K. Al Mouslem, Mohammed Almaghrabi   +11 more
doaj   +4 more sources

Targeting Shikimate Kinase Pathway of Acinetobacter baumannii: A Structure-Based Computational Approach to Identify Antibacterial Compounds [PDF]

Journal of Tropical Medicine, 2023
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium that has developed multidrug resistance (MDR) to most of today’s antibiotics, posing a significant risk to human health.
Aparna Shil, Most. Afrin Akter, Arafin Sultana, Sajal Kumar Halder, Mahbubul Kabir Himel   +4 more
doaj   +2 more sources

Finding the First Potential Inhibitors of Shikimate Kinase from Methicillin Resistant Staphylococcus aureus through Computer-Assisted Drug Design [PDF]

Molecules, 2021
Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto, Alfredo Téllez-Valencia, Erick Sierra-Campos, Mónica Valdez-Solana, Jorge Cisneros-Martínez, Marcelo Gómez Palacio-Gastélum, Adriana Castillo-Villanueva, Claudia Avitia-Domínguez   +7 more
doaj   +2 more sources

Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia. [PDF]

Int J Mol Sci, 2022
In plants, the shikimate pathway is responsible for the production of aromatic amino acids L-tryptophan, L-phenylalanine, and L-tyrosine. L-Phenylalanine is the upstream substrate of flavonoid and anthocyanin synthesis. Shikimate kinase (SK) catalyzes the phosphorylation of the C3 hydroxyl group of shikimate to produce 3-phosphate shikimate (S3P), the ...
Yuan J, Zhong S, Long Y, Guo J, Yu Y, Liu J.   +5 more
europepmc   +3 more sources

Evolutionary diversification of plant shikimate kinase gene duplicates. [PDF]

PLoS Genetics, 2008
Shikimate kinase (SK; EC 2.7.1.71) catalyzes the fifth reaction of the shikimate pathway, which directs carbon from the central metabolism pool to a broad range of secondary metabolites involved in plant development, growth, and stress responses. In this
Geoffrey Fucile, Shannon Falconer, Dinesh Christendat   +2 more
doaj   +4 more sources

Exploring the Dynamics of Shikimate Kinase through Molecular Mechanics

Biophysica, 2022
Shikimate kinase (SK) enzyme is a suitable target for antimicrobial drugs as it is present in pathogenic microorganisms and absent in mammals. A complete understanding of the functioning of this enzyme can unveil novel methods to inactivate it.
Pedro Ojeda-May
doaj   +3 more sources

Exploring the Dynamics of Holo-Shikimate Kinase through Molecular Mechanics

Biophysica, 2023
Understanding the connection between local and global dynamics can provide valuable insights into enzymatic function and may contribute to the development of novel strategies for enzyme modulation.
Pedro Ojeda-May
doaj   +3 more sources

Repurposing FDA-Approved Agents to Develop a Prototype Helicobacter pylori Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calculations, MD Simulations, and DFT Analysis [PDF]

Pharmaceuticals
Background/Objectives: Helicobacter pylori infects approximately half of the global population, causing chronic gastritis, peptic ulcers, and gastric cancer, a leading cause of cancer mortality.
Abdulaziz H. Al Khzem, Tagyedeen H. Shoaib, Rua M. Mukhtar, Mansour S. Alturki, Mohamed S. Gomaa, Dania Hussein, Nada Tawfeeq, Mohsina Bano, Mohammad Sarafroz, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o   +11 more
doaj   +2 more sources

Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. [PDF]

Perspect Medicin Chem, 2015
Owing to the persistence of tuberculosis (TB) as well as the emergence of multidrug-resistant and extensively drug-resistant (XDR) forms of the disease, the development of new antitubercular drugs is crucial. Developing inhibitors of shikimate kinase (SK) in the shikimate pathway will provide a selective target for antitubercular agents.
Gordon S, Simithy J, Goodwin DC, Calderón AI.   +3 more
europepmc   +4 more sources

Molecular cloning and functional characterization of the shikimate kinase gene from Baphicacanthus cusia [PDF]

Frontiers in Plant Science
Baphicacanthus cusia (Nee) Bremek, a perennial herbaceous plant with medicinal properties, has limited genomic insights regarding the genes involved in its indole alkaloid biosynthesis pathway.
Yuxiang Huang, Yuxiang Huang, Yuxiang Huang, Hexin Tan, Qing Li, Xunxun Wu, Zhiying Guo, Zhiying Guo, Junfeng Chen, Lei Zhang, Yong Diao   +10 more
doaj   +2 more sources