The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. [PDF]
PLoS ONE, 2013 Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M.
Leonardo Astolfi Rosado +6 more
doaj +2 more sources
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +2 more sources
Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone. [PDF]
Biochim Biophys Acta Proteins Proteom, 2018 Ilimaquinone (IQ), a marine sponge metabolite, has been considered as a potential therapeutic agent for various diseases due to its broad range of biological activities. We show that IQ irreversibly inactivates Mycobacterium tuberculosis shikimate kinase (MtSK) through covalent modification of the protein.
Simithy J +6 more
europepmc +5 more sources
Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids. [PDF]
Biochemistry, 2018 Tuberculosis represents a significant public health crisis. There is an urgent need for novel molecular scaffolds against this pathogen. We screened a small library of marine-derived compounds against shikimate kinase from Mycobacterium tuberculosis ( MtSK), a promising target for antitubercular drug development.
Simithy J +10 more
europepmc +5 more sources
Comparative transcriptomic dynamics reveal molecular responses of susceptible and resistant Triticum aestivum genotypes to wheat stripe mosaic virus [PDF]
Scientific ReportsSoil-borne wheat mosaic disease (SBWMD), caused by wheat stripe mosaic virus (WhSMV), poses an emerging threat to wheat production in South America. In this study, we analyzed the transcriptomic responses of two Triticum aestivum genotypes exhibiting ...
Samara Campos Nascimento +9 more
doaj +2 more sources
Interplay of rice vitamin E under osmotic and extreme temperature stresses revealed by a comparative transcriptomic approach [PDF]
BMC Plant BiologyBackground Rice (Oryza sativa L.) is vulnerable to abiotic challenges. Understanding stress response mechanisms is therefore a priority for enhancing rice development. Tocopherol is a known antioxidant that helps plants adapt to various abiotic stresses.
Sara Kazemzadeh +3 more
doaj +2 more sources
Combined transcriptomic and metabolomic analyses reveal the pharmacognostic mechanism of the metabolism of flavonoids in different parts of Polygonum capitatum [PDF]
The Plant GenomeThe plant Polygonum capitatum (P. capitatum) contains a variety of flavonoids that are distributed differently among different parts. Nevertheless, differentially expressed genes (DEGs) associated with this heterogeneous distribution have not been ...
Jie Yang +7 more
doaj +2 more sources
Putative type III effector SkP48 of Bradyrhizobium sp. DOA9 encoding a SUMO protease blocks nodulation in Vigna radiata [PDF]
Scientific ReportsBradyrhizobium sp. DOA9 can nodulate a wide spectrum of legumes; however, unlike other bradyrhizobia, DOA9 carries a symbiotic plasmid harboring type III secretion system (T3SS) and several effector (T3E) genes, one of which encodes a putative type III ...
Pongdet Piromyou +14 more
doaj +2 more sources
Tazobactam selects for multidrug resistance [PDF]
npj Antimicrobials and ResistancePiperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine.
Emma R. Holden +4 more
doaj +2 more sources
Minneola tangelo essential oil exhibits antibacterial activity against multidrug-resistant pathogens while maintaining cell safety [PDF]
BMC Complementary Medicine and TherapiesBackground The significant rise in antibiotic resistance has become an alarming situation urging the search for new antibacterial agents. Nature has always been a limitless source of bioactives with high safety profile.
Nouran M. Fahmy +4 more
doaj +2 more sources