Results 21 to 30 of about 9,573 (184)
In silico approach towards the identification of potential inhibitors from Curcuma amada Roxb against H. pylori: ADMET screening and molecular docking studies [PDF]
BioImpacts, 2021 Introduction: The present study attempts to identify potential targets of H. pylori for novel inhibitors from therapeutic herb, mango ginger (Curcuma amada Roxb.).
G Divyashri +6 more
doaj +1 more source
RETRACTED: Interaction of shikimic acid with shikimate kinase [PDF]
Biochemical and Biophysical Research Communications, 2004 Tuberculosis made a resurgence in the mid-1980s and now kills approximately 3 million people a year. The re-emergence of tuberculosis as a public health threat, the high susceptibility of HIV-infected persons and the proliferation of multi-drug-resistant strains have created a need to develop new drugs.
José Henrique Pereira +7 more
+9 more sources
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
doaj +1 more source
Systemic suppression of the shoot metabolism upon rice root nematode infection [PDF]
, 2014 Hirschmanniella oryzae is the most common plant-parasitic nematode in flooded rice cultivation systems. These migratory animals penetrate the plant roots and feed on the root cells, creating large cavities, extensive root necrosis and rotting.
Bauters, Lander +4 more
core +9 more sources
Structural Basis for Shikimate-Binding Specificity ofHelicobacter pyloriShikimate Kinase [PDF]
Journal of Bacteriology, 2005 ABSTRACTShikimate kinase (EC 2.7.1.71) catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP. As the fifth key step in the shikimate pathway for aromatic amino acid biosynthesis in bacteria, fungi, and plants, but not mammals, shikimate kinase represents an attractive target for the development of new ...
Wen-Chi, Cheng +2 more
openaire +2 more sources
Nature Communications, 2023 Cyanobacteria mutants with improved tolerance to combined high light and high temperature (HLHT) are rarely reported. Here, the authors use a hypermutation system for adaptive laboratory evolution and identify a mutant with improved HLHT tolerance by ...
Huili Sun +8 more
doaj +1 more source
Biophysica, 2021 The chemical step of Shikimate Kinase Helicobacter pylori, involving the transfer of a phosphoryl group, has been studied by using quantum mechanical and molecular mechanical (QM/MM) methods.
Pedro Ojeda-May
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 The production of aromatic compounds by microbial production is a promising and sustainable approach for producing biomolecules for various applications.
Naoki Sato +4 more
doaj +1 more source
A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases
Frontiers in Molecular Biosciences, 2021 Bacterial tyrosine kinases (BY-kinases) and shikimate kinases (SKs) comprise two structurally divergent P-loop containing enzyme families that share similar catalytic site geometries, most notably with respect to their Walker-A, Walker-B, and DxD motifs.
Fatlum Hajredini +5 more
doaj +1 more source
Archaeal Shikimate Kinase, a New Member of the GHMP-Kinase Family [PDF]
Journal of Bacteriology, 2001 ABSTRACTShikimate kinase (EC2.7.1.71) is a committed enzyme in the seven-step biosynthesis of chorismate, a major precursor of aromatic amino acids and many other aromatic compounds. Genes for all enzymes of the chorismate pathway except shikimate kinase are found in archaeal genomes by sequence homology to their bacterial counterparts.
M, Daugherty +3 more
openaire +2 more sources