Results 21 to 30 of about 91,795 (159)

Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients with Talaromyces marneffei Infections

Infection and Drug Resistance, 2022
Zhao-Ming Chen,1,* Xiao-Yun Yang,1,2,* Zheng-Tu Li,1,* Wei-Jie Guan,1,3 Ye Qiu,4 Shao-Qiang Li,1 Yang-Qing Zhan,1 Zi-Ying Lei,5 Jing Liu,4 Jian-Quan Zhang,6 Zhong-Fang Wang,1,2 Feng Ye1 1State Key Laboratory of Respiratory Disease, National ...
Chen ZM, Yang XY, Li ZT, Guan WJ, Qiu Y, Li SQ, Zhan YQ, Lei ZY, Liu J, Zhang JQ, Wang ZF, Ye F   +11 more
doaj  

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias [PDF]

Journal of Clinical Oncology, 2009
Signal transducer and activator of transcription (STAT) proteins comprise a seven-member family of latent cytoplasmic transcription factors that are activated through tyrosine phosphorylation by a variety of cytokines and growth factors. Aberrant activation of STATs accompanies malignant cellular transformation with resultant leukemogenesis ...
Wetzler, Meir, Baumann, Heinz, Benekli, Mustafa   +2 more
openaire   +3 more sources

Activated Signal Transducer and Activator of Transcription (STAT) 3 [PDF]

Cancer Research, 2004
Abstract Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary.
Debra L. Silver, Honami Naora, Jinsong Liu, Wenjun Cheng, Denise J. Montell   +4 more
openaire   +1 more source

Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

Frontiers in Immunology, 2022
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membranes (e.g., mouth, esophagus, and vagina).
Xiaodi Lu, Keming Zhang, Weiwei Jiang, Weiwei Jiang, Hang Li, Yue Huang, Mingwei Du, Jian Wan, Yanyun Cao, Yanyun Cao, Lin Du, Xiaogang Liu, Weihua Pan   +12 more
doaj   +1 more source

STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection

Respiratory Medicine Case Reports, 2020
Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera, Britt Johnson, Mehdi Mirsaeidi   +2 more
doaj   +1 more source

Signal Transducer and Activator of Transcription 3 Mutation with Invasive Eosinophilic Disease

Allergy & Rhinology, 2012
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes of inheritance, autosomal
Kara Crosby D.O., David Swender D.O., Leah Chernin D.O., Said Hafez-Khayyata, Hans Ochs M.D., Haig Tcheurekdjian M.D., Robert Hostoffer D.O.   +6 more
doaj   +1 more source

Expression Levels of Predominant Adipokines and Activations of STAT3, STAT6 in an Experimental Mice Model of Obese Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2019
Obese asthma is a new asthma phenotype. The underlying mechanisms are not clearly understood. Leptin and adiponectin are two predominant adipokines produced by adipose tissue.
Lei Chong, Liu Liu, Lili Zhu, Haiyan Li, Youyou Shao, Hailin Zhang, Gang Yu   +6 more
doaj   +1 more source

Infection-stimulated Anemia Results Primarily from Interferon Gamma-dependent, Signal Transducer and Activator of Transcription 1-independent Red Cell Loss

Chinese Medical Journal, 2015
Background: Although the onset of anemia during infectious disease is commonly correlated with production of inflammatory cytokines, the mechanisms by which cytokines induce anemia are poorly defined.
Zheng Wang, Dong-Xia Zhang, Qi Zhao
doaj   +1 more source

New primers for methylation-specific polymerase chain reaction enhance specificity of detecting STAT1 methylation

Taiwanese Journal of Obstetrics & Gynecology, 2012
Objective: Signal transducer and activator of transcription (STAT)1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Ming-Cheng Chang, Ying-Cheng Chiang, Chih-Ming Ho, Yu-Li Chen, Chi-An Chen, Wen-Fang Cheng, Cheng-Yang Chou   +6 more
doaj   +1 more source

Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis

Skeletal Muscle, 2021
Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda, Toshiya Funabashi   +4 more
doaj   +1 more source