Results 31 to 40 of about 90,535 (152)

ANGPTL3 affects the metastatic potential and the susceptibility of ovarian cancer cells to natural killer cell-mediated cytotoxicity

Heliyon, 2023
High metastatic potential and resistance to immunotherapy lead to poor survival in patients with ovarian cancer. Angiopoietin-like protein 3 is aberrantly expressed and exerts diverse roles in the progression of several cancers.
Yuxian Wu, Yaqun Zheng, Zhijun Jin
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STAT3 (signal transducer and activator of transcription 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on STAT3 (signal transducer and activator of transcription 3), with data on DNA, on the protein encoded, and where the gene is implicated.
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Signal Transducer and Activator of Transcription 3 for the Differentiation of Hepatocellular Carcinoma from Cirrhosis

Chinese Medical Journal, 2017
Background: Overexpression and constitutive activation of signal transducer and activator of transcription (STAT) 3 have been suggested in the tumorigenesis of many human cancers, including multiple carcinomas, melanoma, and lymphoma.
Yan-Ping Li, Wen-Ze Wang, Xue-Qi Chen, Ling-Bo Li, Zhi-Yong Liang, Kun Ru, Jing-Nan Li   +6 more
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Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

Journal of Lipid Research, 2017
Oncostatin M (OSM) is a secreted cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β (OSMR-β).
Xin Zhang, Jing Li, Juan-Juan Qin, Wen-Lin Cheng, Xueyong Zhu, Fu-Han Gong, Zhigang She, Zan Huang, Hao Xia, Hongliang Li   +9 more
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Regulation and function of signal transducer and activator of transcription 3

World Journal of Biological Chemistry, 2014
Laparoscopic surgery is the main treatment method for patients with gastrointestinal malignant tumors. Although laparoscopic surgery is minimally invasive, its tool stimulation and pneumoperitoneum pressure often cause strong stress reactions in patients. On the other hand, gastrointestinal surgery can cause stronger pain in patients, compared to other
Qian-Rong, Qi, Zeng-Ming, Yang
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Construction and characterization of mice with conditional knockout of Stat3 gene in microglia

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To construct mice with conditional knockout of Stat3 gene in microglia based on the Cre-Loxp system and validate their knockout efficiency.Methods·Cx3cr1creERT2 and Stat3fl/fl genotypic mice were bred for conditional knockout mice (CKO) and ...
ZHU Xiaochen, XIE Xinyi, ZHAO Xuri, XU Lina, HE Zhiyan, ZHOU Wei   +5 more
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GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3

Cancer Biology & Therapy
Aim To elucidate the biological functionality and regulatory mechanisms of GdX in breast cancer (BC).Methods The examination of GdX expression in human BC tissues and cell lines was conducted through immunohistochemical (IHC) and Western blot.
Zhilin Chen, Lu Xu, Shibin Lin, Hongjun Huang, Qing Long, Jiwei Liu   +5 more
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Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma

Kaohsiung Journal of Medical Sciences, 2009
In this study, we investigated the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) Tyr705 and suppressor of cytokine signaling 3 (SOCS3) in urothelial carcinoma (UC).
Wan-Ting Huang, Sheau-Fang Yang, Chun-Chieh Wu, Wan-Tzu Chen, Ya-Chun Huang, Yue-Chiu Su, Chee-Yin Chai   +6 more
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Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3

BMB Reports, 2020
Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of various cancer cells.
Kim, Ba Reum, Ha, Jain, Kang, Eunjeong, Cho, Sayeon   +3 more
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Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis

Frontiers in Pharmacology, 2019
Background: Breast cancer is the most common female cancer with considerable metastatic potential, which urges the need for developing novel potential drug candidate to inhibit tumor metastasis.
Yali Li, Yali Li, Cailing Gan, Yange Zhang, Yan Yu, Chen Fan, Yuanle Deng, Qianyu Zhang, Xi Yu, Yiwen Zhang, Liqun Wang, Fang He, Yongmei Xie, Tinghong Ye, Wenya Yin   +14 more
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