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Topical Application of Artesunate Ameliorates Psoriatic Keratinization and Inflammation via Molecular Modulations Based on Both Human and Mouse Models. [PDF]
ACS OmegaHuang ZZ +8 more
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Synthetic Studies toward 5,6,7,3',4'-Monomethoxytetrahydroxyflavones: Synthesis of Pedalitin. [PDF]
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Natural flavonoid sinensetin inhibits cisplatin-induced pyroptosis and attenuates intestinal injury
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023The demand of exploring strategies to enhance chemotherapy drug efficacy and alleviate adverse effects by using natural compounds is increasing. Sinensetin (SIN) is a kind of natural flavonoids with anti-inflammatory activities. However, its protective impact on chemotherapy-induced adverse effects has not been well demonstrated.
Yue, Li +10 more
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Critical Reviews in Food Science and Nutrition, 2023
Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on the bioavailability of sinensetin and its derivatives was reviewed and the potential ameliorative effects of metabolic syndrome in humans were evaluated. Sinensetin and its
Mutang Zhang +8 more
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Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on the bioavailability of sinensetin and its derivatives was reviewed and the potential ameliorative effects of metabolic syndrome in humans were evaluated. Sinensetin and its
Mutang Zhang +8 more
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Die Pharmazie, 2022
In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI,
Yi-Lun Wang, Yi-Lun Wang +2 more
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In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI,
Yi-Lun Wang, Yi-Lun Wang +2 more
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Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway
Tissue and Cell, 2022Pulmonary fibrosis is a fatal lung disease characterized by progressive fibroblast proliferation and extensive extracellular matrix (ECM) deposition. Although great efforts have been placed to understand the pathogenesis and explore therapeutic strategies, the treatment options for pulmonary fibrosis are very limited and the prognosis of pulmonary ...
Xuan, Wan +5 more
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Food & Function, 2022
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.
Zhendong Liu +6 more
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Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.
Zhendong Liu +6 more
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Chemie in unserer Zeit, 2013
AbstractSinensetin wurde aus kaltgepresstem Orangenschalenöl isoliert und aus Ethanol umkristallisiert. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder im online unter www.chiuz.de zusätzlichen Material zu diesem Artikel wiedergegeben.
Katrin Steinke +5 more
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AbstractSinensetin wurde aus kaltgepresstem Orangenschalenöl isoliert und aus Ethanol umkristallisiert. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder im online unter www.chiuz.de zusätzlichen Material zu diesem Artikel wiedergegeben.
Katrin Steinke +5 more
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Journal of Agricultural and Food Chemistry, 2021
As one of the major polymethoxyflavones in citrus peels, sinensetin (Sin) has been reported to possess numerous bioactivities. However, its detailed in vivo metabolic fate has not been uncovered yet. In the present study, the possible metabolites of Sin were synthesized, and all five mono-demethylated metabolites were successfully identified via ...
Xiaoqi Wang +4 more
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As one of the major polymethoxyflavones in citrus peels, sinensetin (Sin) has been reported to possess numerous bioactivities. However, its detailed in vivo metabolic fate has not been uncovered yet. In the present study, the possible metabolites of Sin were synthesized, and all five mono-demethylated metabolites were successfully identified via ...
Xiaoqi Wang +4 more
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Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes
Phytotherapy Research, 2012Sinensetin is a rare polymethoxylated flavone found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in mature 3T3‐L1 adipocytes. Sinensetin decreased the expression of sterol regulatory element‐binding protein 1c (SREBP1c), suggesting its antiadipogeneic property via downreguation of SREBP1c. Also,
Seong-Il, Kang +3 more
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