Results 171 to 180 of about 1,840 (184)

Disposable array sensor strip for quantification of sinensetin in Orthosiphon stamineus Benth samples

Microchimica Acta, 2008
A disposable screen printed array sensor strip based on self-plasticized lipid membranes combined with chemometric algorithm has been developed and applied for quantification of Orthosiphon stamineus Benth extracts. Sinensetin, a pharmacologically active flavonoid in Orthosiphon stamineus Benth, was quantified with the sensor system using standard ...
Ahmad, MN, Mee Sim, M. Y, Cheen, C. C, Shafiqul Islam, A. K. M, Ismail, Z, Surif, M, Shakaff, A. Y. Md, Lvova, L   +7 more
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Sinensetin ameliorates high glucose‐induced diabetic nephropathy via enhancing autophagy in vitro and in vivo

Journal of Biochemical and Molecular Toxicology, 2023
AbstractDiabetic nephropathy (DN) affects around 40% of people with diabetes, the final outcome of which is end‐stage renal disease. The deficiency of autophagy and excessive oxidative stress have been found to participate in the pathogenesis of DN. Sinensetin (SIN) has been proven to have strong antioxidant capability. However, the effect of SIN on DN
Zili Kong, Wenshan Lv, Yunyang Wang, Yajing Huang, Kui Che, Huiqi Nan, Yu Xin, Jiaxuan Wang, Jintao Chen, Yangang Wang, Jingwei Chi   +10 more
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Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3′,4′-pentamethoxyflavone (Sinensetin)

Biochemical and Biophysical Research Communications, 2002
Multidrug resistance (MDR) cells can be sensitized to anticancer drugs when treated concomitantly with chemosensitizers. In this study, chemosensitizing effects of 5,6,7,3',4'-pentamethoxyflavone (sinensetin) and its analogs were investigated with respect to in vitro efficacy and structure-activity relationship.
Cheol Hee, Choi, Kyung Hoon, Sun, Chun San, An, Jin Cheol, Yoo, Kyung Soo, Hahm, In Hwa, Lee, Jae Kyung, Sohng, Youn Chul, Kim   +7 more
openaire   +2 more sources

Structural changes and anti-hepatocellular carcinoma activity of interferon-γ after interaction with sinensetin

International Journal of Biological Macromolecules, 2023
Exploring the interaction of small molecules with therapeutic proteins can provide useful information about development of ligand-protein complexes as synergistically therapeutic platforms. In this study, the interaction of sinensetin with human interferon gamma (IFNγ) was evaluated experimentally and theoretically.
Feiling, Feng, Tiehua, Li, Yingchao, Liang, Wei, Gao, Liang, Yang   +4 more
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Identification of sinensetin and nobiletin as major antitrypanosomal factors in a citrus cultivar

Experimental Parasitology, 2019
Cases of human African trypanosomiasis caused by infection with a protozoan parasite, Trypanosoma brucei, are decreasing due to enhanced surveillance and control. However, effective and safe treatments for this disease are still needed. In this study, we investigated the antitrypanosomal activity of citrus fruit peel.
Masayuki, Nakanishi, Mami, Hino, Morio, Yoshimura, Yoshiaki, Amakura, Hiroshi, Nomoto   +4 more
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Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma

Anti-Cancer Drugs, 2019
The present study was carried out to explore the effect of sinensetin in human T-cell lymphoma Jurkat cells and to reveal the underlying molecular mechanisms. We found that sinensetin significantly impeded Jurkat cell proliferation in a dose-dependent and time-dependent manner.
Kok-Tong, Tan, Meng-Xian, Lin, Shih-Chao, Lin, Yu-Tang, Tung, Sheng-Hao, Lin, Chi-Chien, Lin   +5 more
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Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α

Bioscience, Biotechnology, and Biochemistry, 2012
Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Hye-Sun, Shin, Seong-Il, Kang, Seon-A, Yoon, Hee-Chul, Ko, Se-Jae, Kim   +4 more
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[Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011
To study the effects and mechanisms of sinensetin on proliferation and apoptosis of human AGS gastric cancer cells.MTT assay was used to detect the growth inhibition rates of human AGS gastric cancer cells treated with sinsesectin in different concentrations and times. The cell cycle distribution was measured by flow cytometry.
Yang, Dong, Guang, Ji, Aili, Cao, Jianrong, Shi, Hailian, Shi, Jianqun, Xie, Dazheng, Wu   +6 more
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Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels

Hypertension Research, 2018
Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still very little information regarding the vasorelaxant effect of sinensetin due to a lack of ...
Mun Fei, Yam, Chu Shan, Tan, Ruan, Shibao   +2 more
openaire   +2 more sources

Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro

Food Chemistry, 2020
For clementine juice, previous data indicate a possible food-drug interaction with substrates of key enzymes responsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2). However, which compounds in clementine juice are responsible for these effects are unknown.
Johanna Weiss, Giuseppe Gattuso, Davide Barreca, Walter Emil Haefeli   +3 more
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