Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Investigation of proton single-event transient in CMOS image sensor
With the increasingly widespread application of CMOS image sensors (CIS) in radiation environments, such as aerospace, their radiation effects have gained attention.
Zhigang Peng +10 more
doaj +1 more source
Study on Single Event Effects of Enhanced GaN HEMT Devices under Various Conditions
GaN HEMT devices are sensitive to the single event effect (SEE) caused by heavy ions, and their reliability affects the safe use of space equipment. In this work, a Ge ion (LET = 37 MeV·cm2/mg) and Bi ion (LET = 98 MeV·cm2/mg) were used to irradiate ...
Xinxiang Zhang +11 more
doaj +1 more source
Single Event Transient Tolerance Analysis in 8051 Microprocessor Using Scan Chain
As semi-conductor manufacturing technology evolves; the single event transient problem becomes more significant issue. Single event transient has a critical impact on both combinational and sequential logic circuits, so it is important to evaluate the ...
Jong Kang Park +2 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analysis of SET Reconvergence and Hardening in the Combinational Circuit Using a SAT-Based Method
The reconvergence-phenomenon is common in modern circuit design. It occurs when the signal reconvenes at a certain point through multiple sensitized paths. It affects the soft error estimation and hardening. It is complicated to analyze the reconvergence-
Chang Liu, Long Zhang, Xu He, Yang Guo
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Analysis of Single Event Transient in SOI GaN-Based FinFET Due to Heavy-Ion Irradiation
GaN devices offer unrivaled efficiency, high-frequency performance, and superior radiation tolerance over traditional silicon technologies, making them well-suited for space applications.
P. S. Rajakumar, S. Satheesh Kumar
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Reset Tree-Based Optical Fault Detection
In this paper, we present a new reset tree-based scheme to protect cryptographic hardware against optical fault injection attacks. As one of the most powerful invasive attacks on cryptographic hardware, optical fault attacks cause semiconductors to ...
Howon Kim +3 more
doaj +1 more source

