Results 11 to 20 of about 5,294 (215)

A novel and evolutionarily distinct flavoprotein monooxygenase drives skatole degradation in Rhodococcus [PDF]

Applied and Environmental Microbiology
Skatole (3-methylindole), a persistent and toxic N-heterocyclic aromatic pollutant, poses significant bioremediation challenges due to poorly defined biodegradation processes.
Nan Meng, Genxiu Li, Jiaxin Zhang, Jingwen Zhu, Xutong Kang, Jiahao Duan, Qiao Ma   +6 more
doaj   +2 more sources

Long‐Term Changes in Olfactory Threshold During Rehabilitation After Total Laryngectomy: A Preliminary Study [PDF]

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
In patients who underwent laryngectomy, olfactory thresholds recovered earlier, while identification abilities recovered later. Recovery speed varied by odor, with faster recovery for odors with physiological significance like putrid smells. ABSTRACT Objectives This study aimed to evaluate the time‐dependent changes in olfactory threshold and ...
Yumi Yamaguchi, Toshiro Umezaki, Daisuke Murakami, Takeshi Murakami, Yoshikazu Kikuchi, Nobuyuki Sato, Motohiro Sawatsubashi, Kazuo Adachi, Mioko Matsuo, Takashi Nakagawa   +9 more
wiley   +2 more sources

Microbiome‐Based Clustering Identifies Glycemic Control‐Related Subtypes in Youth With Recent‐Onset Type 1 Diabetes [PDF]

MedComm, Volume 7, Issue 4, April 2026.
Microbiome‐based clustering investigated possible glycemic control‐related endotypes in youth with recent‐onset T1D, and found a potential role of Bacteroides and skatole production in glycemic control. This study offers novel perspectives on the influence of intestinal microbes and its metabolites in T1D heterogeneity and lays a foundation for future ...
Huiling Tan, Yu Ding, Zhaohe Gu, Xulin Wang, Jing Wang, Tian Wei, Xiaoya Zhang, Lanxin Pan, Yu Shi, Shiru Chang, Chuang Guo, Jianping Weng, Xueying Zheng, Tong Yue   +13 more
wiley   +2 more sources

Indole-3-Acetic Acid as a Putative Selective AhR Modulator Counteracts Skatole-Induced Dual-Hit Toxicity in Colorectal Cancer Cells [PDF]

Toxins
The rising incidence of colorectal cancer (CRC) in modernized societies is linked to diet-induced dysbiosis, characterized by a critical metabolic divergence: the depletion of protective indole-3-acetic acid (IAA) concurrent with the accumulation of ...
Chihiro Takei, Hidehisa Shimizu
doaj   +2 more sources

Skatole metabolites in urine as a biological marker of pigs with enhanced hepatic metabolism

Animal, 2016
Boar taint is a quality defect in meat, related to accumulation of skatole and androstenone in male pigs. The levels of skatole and its main metabolites in plasma and urine samples were measured with a validated liquid chromatography-MS method and ...
C. Brunius, J.K. Vidanarachchi, J. Tomankova, K. Lundström, K. Andersson, G. Zamaratskaia   +5 more
doaj   +3 more sources

Effects of Saccharomyces cerevisiae on the regulation of skatole, microorganisms, and tryptophan metabolites in vitro fermentation of pig [PDF]

Microbiology Spectrum
Skatole (3-methylindole), one of the most malodorous compounds from swine manure, poses serious risks to animal, human, and environmental health. Therefore, it has become a serious concern in livestock farming.
Xiaoli Gao, Shengwei Zhang, Shanshan Ge, Qiaoli Yang, Shuangbao Gun   +4 more
doaj   +2 more sources

Molecular Analysis of Indole and Skatole Decomposition Metabolism in Acinetobacter piscicola p38 Utilizing Biochemical and Omics Approaches [PDF]

Microorganisms
Indole and skatole (3-methylindole, C9H9N) are common nitrogen-containing heterocyclic pollutants found in waste, wastewater treatment plants, and public restrooms and are the most notorious compounds in animal feces.
Zhonghao Wang, Jiajin Sun, Pu Yang, Wanjun Zhang, Yihong Jiang, Qiang Liu, Yunqi Yang, Ruirong Hao, Gang Guo, Wenjie Huo, Qiang Zhang, Qinghong Li   +11 more
doaj   +2 more sources

Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes [PDF]

Research
Osteoarthritis (OA) is the most prevalent joint disease, yet effective disease-modifying OA drugs (DMOADs) remain elusive. Targeting macrophage polarization has emerged as a promising avenue for OA treatment.
Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren   +17 more
doaj   +2 more sources

Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease [PDF]

Cells
Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), in intestinal epithelial cells significantly contribute to inflammatory bowel disease (IBD) and colorectal cancer (CRC).
Katsunori Ishii, Kazuma Naito, Dai Tanaka, Yoshihito Koto, Koichi Kurata, Hidehisa Shimizu   +5 more
doaj   +2 more sources

Isolable Cysteine Sulfenyl Iodide: Stabilization by a Molecular Cradle, Crystal Structure, and Biologically Relevant Reactivity [PDF]

ChemBioChem, Volume 26, Issue 24, December 11, 2025.
An isolable cysteine sulfenyl iodide (Cys–SI) stabilized by a molecular cradle is reported. X‐ray analysis and reactivity studies reveal hydrolysis to sulfenic acid, electrophilic substitution with indoles, and high reactivity toward amines and dimedone, providing direct evidence for long‐standing proposals on iodine‐mediated protein modification ...
Shotaro Otaka, Tsukasa Sano, Shohei Sase, Satoru Kuwano, Kei Goto   +4 more
wiley   +2 more sources