Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic Switch [PDF]
Journal of XenobioticsThe escalating consumption of red meat is a potent environmental risk factor for inflammatory bowel disease (IBD), which is characterized by compromised expression of the xenobiotic transporter P-glycoprotein (MDR1/ABCB1). While gut microbiota metabolize
Kazuma Naito +3 more
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In Vitro Assessment of the Effectiveness of Mineral Adsorbents in Sequestering Boar Taint Compounds [PDF]
AnimalsThe utility of four mineral adsorbents as potential feed additives to bind the boar taint compounds, androstenone and skatole, was assessed with an in vitro system.
Sanghyuk Park, James Squires
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Hepatic Gene Expression and Metabolite Profiles of Androstenone and Skatole Relative to Plasma Estrone Sulfate Levels in Boars [PDF]
BiomoleculesTesticular steroids can alter the activity and expression of enzymes within the liver and may influence the metabolism of skatole and androstenone, which are responsible for boar taint.
Christine Bone, E. James Squires
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Influence of Different Plant Extracts on CYP-Mediated Skatole and Indole Degradation in Pigs [PDF]
AnimalsOne of the primary substances responsible for the unpleasant odor in boar meat is skatole. Enzymes belonging to the cytochrome P450 (CYP) family play a pivotal role in the hepatic clearance of skatole.
Philipp Marro +2 more
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Direct Fluoroformylation of the C3‐Position of Indoles with 2,4‐Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source [PDF]
ChemistryOpen, Volume 15, Issue 3, March 2026.Indoles bearing acyl fluoride moieties are generally obtained by dehydroxyfluorination of carboxylic acids or by fluoroformylation mediated by palladium catalysts with the disadvantage of requiring toxic reagents or very high pressures. We describe herein the direct, metal‐free, and rapid C3‐fluoroformylation of electro‐enriched indoles using ...
Lilian Wisson +5 more
wiley +2 more sources
Fermentation, 2023 The purpose of this work was to study the dose effects of fruit oligosaccharide (FOS) supplementation on rumen fermentation parameters, methane (CH4) production and skatole production.
Liyan Wang +8 more
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Effect of feeding fermentable fibrerich feedstuffs on meat quality with emphasis on chemical and sensory boar taint in entire male and female pigs [PDF]
, 2008 Skatole, androstenone and other compounds such as indole cause boar taint in entire male pork. However, female pigs also produce skatole and indole. The purpose of this experiment was to minimise boar taint and increase overall impression of sensory ...
Byrne, D.V. +6 more
core +1 more source
Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors
eLife, 2022 The southern house mosquito, Culex quinquefasciatus, utilizes two odorant receptors, CquiOR10 and CquiOR2, narrowly tuned to oviposition attractants and well conserved among mosquito species.
Flavia P Franco +4 more
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In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]
, 2011 Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo +2 more
core +1 more source
Interaction between dietary digestible tryptophan and soy oligosaccharides in broiler chickens: effects on caecal skatole level and microflora [PDF]
Animal Bioscience, 2023 Objective This study was conducted to evaluate the interactive effects of dietary digestible tryptophan (dTry) and soy oligosaccharides (SO) on growth performance, caecal skatole level, and microflora of broiler chickens aged from 14 to 42 days.
Jing Chen +4 more
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