Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics [PDF]
, 2013 core +1 more source
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types [PDF]
core +1 more source
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures [PDF]
Nature Communications, 2015 The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.
Tommy Stödberg +2 more
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SLC12A5 interacts and enhances SOX18 activity to promote bladder urothelial carcinoma progression via upregulating MMP7 [PDF]
Cancer Science, 2020 AbstractSolute carrier family 12 member 5 (SLC12A5) has an oncogenic role in bladder urothelial carcinoma. The present study aimed to characterize the molecular mechanisms of SLC12A5 in bladder urothelial carcinoma pathogenesis. Functional assays identified that in bladder urothelial carcinoma SLC12A5 interacts with and stabilizes SOX18, and then ...
Long Wang, Qun Zhang, Dan Xie
exaly +3 more sources
Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing [PDF]
Cell Research, 2014 Single-cell sequencing is a powerful tool for delineating clonal relationship and identifying key driver genes for personalized cancer management. Here we performed single-cell sequencing analysis of a case of colon cancer. Population genetics analyses identified two independent clones in tumor cell population.
Chang Yu, Xiaotian Yao, William Kk Wu
exaly +4 more sources
Overexpression of SLC12A5 is associated with tumor progression and poor survival in ovarian carcinoma [PDF]
International Journal of Gynecological Cancer, 2019 The solute carrier family 12 member 5 (SLC12A5) gene is playing a putative oncogenic role in colorectal carcinoma. However, the status of SLC12A5 amplification and expression in ovarian carcinoma and its potential clinical and/or prognostic significance has not yet been investigated.In the present study, semi-quantitative staining and fluorescence in ...
Feng-Wei Wang, Dan Xie
exaly +3 more sources
Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction
Brain Research, 2019 SLC12A5 encodes K+-Cl- cotransporter 2 (KCC2), which is the main Cl- extruder of neurons, and renders the proper inhibitory function of the neurotransmitters γ-aminobutyric acid (GABA) and glycine. Thus, any variant in SLC12A5, if it causes dysfunction of KCC2, could be pathogenic for neurological and psychiatric disorders by disrupting inhibition and ...
Atsuo Fukuda, Miho Watanabe
exaly +3 more sources
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SLC12A5 as a novel potential biomarker of glioblastoma multiforme
Molecular Biology Reports, 2023Glioblastoma multiforme (GBM) is the most prevalent and malignant intracranial tumor with significant features of dismal prognosis and limited therapeutic solutions. Consequently, the present studies are committed to exploring potential biomarkers through bioinformatics analysis, which may serve as valuable prognostic predictors or novel therapeutic ...
Jiakai Chen +3 more
openaire +2 more sources
SLC12A5 antibody characterization report
2023This report guides researchers to select the most appropriate antibodies for Solute Carrier Family 12 Member 5. We used an antibody characterization pipeline based on knockout overexpression (KOOE) and knockout (KO) cells to perform head-to-head comparisons of commercial antibodies for SLC12A5 by immunoblot (Western blot) and immunofluorescence.
Garcia, Julio, Gelova, Zuzana
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