Results 101 to 110 of about 1,113 (145)

Genetic and Epigenetic Modifiers of Ketogenic Diet Responses: Roles of Sex and Age

Obesities
The ketogenic diet (KD) is a metabolic intervention characterized by high fat and very low carbohydrate intake, showing significant metabolic, neuroprotective, and therapeutic effects.
Marko Sablić, Viktoria Čurila, Senka Blažetić, Marta Balog, Marija Heffer, Antonio Kokot, Vedrana Ivić   +6 more
doaj   +1 more source

Mitochondrial disease in children : from clinical presentation to genetic background [PDF]

, 2017
Mitochondrial disorders are amongst the most common groups of inborn errors of metabolism. They are caused by deficiencies in the final pathway of the cellular energy production, the mitochondrial respiratory chain.
Naess, Karin
core   +1 more source

Development of KCC2 therapeutics to treat neurological disorders

Frontiers in Molecular Neuroscience
KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS.
Shilpa D. Kadam, Shane V. Hegarty
doaj   +1 more source

Effect of protein synthesis inhibitors on the function of the neuronal K-Cl cotransporter KCC2 [PDF]

, 2010
The Cl- and HCO3- electrochemical gradients across the plasma membrane dictate the electrical consequences of GABAA receptor (GABAAR) function and thereby play a significant role in neuronal GABA-mediated signalling. In adult pyramidal neurons, responses
Puskarjov, Martin
core  

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function [PDF]

, 2015
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery.
Freedman, Robert, Graw, Sharon, Leonard, Sherry, Lester, Henry A., Ross, Randal G., Sinkus, Melissa L.   +5 more
core   +1 more source

Single-cell transcriptome analysis identifies a novel tumor-associated macrophage subtype predicting better prognosis in pancreatic ductal adenocarcinoma

Frontiers in Cell and Developmental Biology
BackgroundCharacterized by an immune-suppressive tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) is well-known for its poor prognosis. Tumor associated macrophages (TAMs) play a critical role in PDAC TME.
Xiaonan Wang, Dongyi Li, Bo Zhu, Zichun Hua, Zichun Hua, Zichun Hua, Zichun Hua   +6 more
doaj   +1 more source

Genome-wide association analysis of eggshell color of an F2 generation population reveals candidate genes in chickens

Animal
Eggshell color is an important visual characteristic that affects consumer preferences for eggs. Eggshell color, which has moderate to high heritability, can be effectively enhanced through molecular marker selection.
X.G. Wang, M.M. Shen, J. Lu, T.C. Dou, M. Ma, J. Guo, K.H. Wang, L. Qu   +7 more
doaj   +1 more source

Additional file 5 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 5.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 6 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 6.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 1 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 1.Figure S1 (a) Analysis of EZH2's impact on prognosis in recurrent gliomas using the CGGA database. (b) Evaluation of EZH2's prognostic influence using the TCGA database. (c) Expression levels of SLC12A5 in different types of gliomas. (d) Influence of SLC12A5 on the prognosis of primary gliomas in the CGGA database.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source