Results 81 to 90 of about 1,526 (158)

The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach [version 2; referees: 2 approved]

F1000Research, 2016
Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One
Ravi Kiran Reddy Kalathur, Joaquin Giner-Lamia, Susana Machado, Tania Barata, Kameshwar R S Ayasolla, Matthias E. Futschik   +5 more
doaj   +1 more source

Global gene expression profiling in human lung cells exposed to cobalt

BMC Genomics, 2007
Background It has been estimated that more than 1 million workers in the United States are exposed to cobalt. Occupational exposure to 59 Co occurs mainly via inhalation and leads to various lung diseases.
Steinmetz Gerard, Ruat Sylvie, Prat Odette, Berenguer Frederic, Malard Veronique, Quemeneur Eric   +5 more
doaj   +1 more source

Neuronal K-Cl Cotransporter : Transcriptional Mechanisms of KCC2 Gene Regulation [PDF]

, 2010
K-Cl cotransporter 2 (KCC2) maintains a low intracellular Cl concentration required for fast hyperpolarizing responses of neurons to classical inhibitory neurotransmitters γ-aminobutyric acid (GABA) and glycine.
Uvarov, Pavel
core  

Gene expression in the dorsal root ganglion and the cerebrospinal fluid metabolome in polyneuropathy and opioid tolerance in rats

IBRO Neuroscience Reports
First-line pharmacotherapy for peripheral neuropathic pain (NP) of diverse pathophysiology consists of antidepressants and gabapentinoids, but only a minority achieve sufficient analgesia with these drugs.
Fredrik H.G. Ahlström, Hanna Viisanen, Leena Karhinen, Vidya Velagapudi, Kim J. Blomqvist, Tuomas O. Lilius, Pekka V. Rauhala, Eija A. Kalso   +7 more
doaj   +1 more source

Genetic and Epigenetic Modifiers of Ketogenic Diet Responses: Roles of Sex and Age

Obesities
The ketogenic diet (KD) is a metabolic intervention characterized by high fat and very low carbohydrate intake, showing significant metabolic, neuroprotective, and therapeutic effects.
Marko Sablić, Viktoria Čurila, Senka Blažetić, Marta Balog, Marija Heffer, Antonio Kokot, Vedrana Ivić   +6 more
doaj   +1 more source

Validation of the purity of the cell populations used for the mRNA analysis Striatal cells were isolated from wild type and transgenic mice at 6 weeks of age 2 hours after treatment with HSP990 (12 mg/kg) or vehicle and sorted based on Gfp expression.

, 2015
RT-qPCR analysis of the expression levels of (A) Slc12a5, Drd1a, Drd2, Aldh1l1, Gfap and Mbp and (B) Gfp in GFP+ cells isolated from mice treated with HSP990 or vehicle.
Saliha Moussaoui (764430), Gillian P. Bates (135712), Hayley Lazell (764429), Alisia Carnemolla (764428)   +3 more
core   +1 more source

CUHK electronic theses & dissertations collection

, 2014
Background & Aims: By whole genome sequencing, we identified for the first time that solute carrier family 12 member 5 (SLC12A5) gene located on chromosome 20q13.12 was amplified in colorectal cancer (CRC).

core  

Additional file 6 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 6.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Genome-wide association analysis of eggshell color of an F2 generation population reveals candidate genes in chickens

Animal
Eggshell color is an important visual characteristic that affects consumer preferences for eggs. Eggshell color, which has moderate to high heritability, can be effectively enhanced through molecular marker selection.
X.G. Wang, M.M. Shen, J. Lu, T.C. Dou, M. Ma, J. Guo, K.H. Wang, L. Qu   +7 more
doaj   +1 more source

Additional file 4 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 4.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source