Results 81 to 90 of about 1,113 (145)

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment

Channels
Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter.
Morgan Kok, Elias Aizenman, Christopher J. Guerriero, Jeffrey L. Brodsky   +3 more
doaj   +1 more source

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission

Cells, 2019
The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases.
Bor Luen Tang
doaj   +1 more source

Integrated Analysis to Evaluate the Prognostic Value of Signature mRNAs in Glioblastoma Multiforme

Frontiers in Genetics, 2020
BackgroundGliomas are the most common intracranial tumors and are classified as I–IV. Among them, glioblastoma multiforme (GBM) is the most common invasive glioma with a poor prognosis.
Ji’an Yang, Long Wang, Zhou Xu, Liquan Wu, Baohui Liu, Junmin Wang, Daofeng Tian, Xiaoxing Xiong, Qianxue Chen   +8 more
doaj   +1 more source

ABC Efflux Transporters and Solute Carriers in the Early Developing Brain of a Marsupial Monodelphis domestica (South American Gray Short‐Tailed Opossum)

Journal of Comparative Neurology, Volume 532, Issue 7, July 2024.
We compared transcriptomic profiles and functionality of ABC and SLC transporters in marsupial Monodelphis domestica brain and eutherian rat brain and placenta. Data indicate that despite its extreme immaturity, Monodelphis brain may compensate for a lack of placental protection during early brain development by upregulating protective mechanisms ...
Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Fiona Qiu, Ana C. C. Leandro, Paul D. Callaghan, Joanne E. Curran, John L. VandeBerg, Norman R. Saunders   +8 more
wiley   +1 more source

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +1 more source

Comprehensive analysis of lncRNA‐associated ceRNA network reveals novel potential prognostic regulatory axes in glioblastoma multiforme

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Deciphering the lncRNA‐associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers for GBM by constructing a lncRNA‐miRNA‐mRNA network.
Maryam Bazrgar, Seyed Amir Mirmotalebisohi, Mohsen Ahmadi, Parisa Azimi, Leila Dargahi, Hakimeh Zali, Abolhassan Ahmadiani   +6 more
wiley   +1 more source

Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs

Open Biology
Frontotemporal lobe abnormalities are linked to neuropsychiatric disorders and cognition, but the role of cellular heterogeneity between temporal lobe (TL) and frontal lobe (FL) in the vulnerability to genetic risk factors remains to be elucidated.
Jiatong Ji, Honglu Chao, Huimei Chen, Jun Liao, Wenqian Shi, Yangfan Ye, Tian Wang, Yongping You, Ning Liu, Jing Ji, Enrico Petretto   +10 more
doaj   +1 more source

Genetic landscape of multiple sclerosis susceptibility by leveraging multi-omics data [PDF]

, 2018
The main objective of the research studies presented in this thesis is to study the genetic variants and the expression of genes that relate to Multiple Sclerosis (MS).
James, Tojo
core   +1 more source

The olfactory bulb: A neuroendocrine spotlight on feeding and metabolism

Journal of Neuroendocrinology, Volume 36, Issue 6, June 2024.
Abstract Olfaction is the most ancient sense and is needed for food‐seeking, danger protection, mating and survival. It is often the first sensory modality to perceive changes in the external environment, before sight, taste or sound. Odour molecules activate olfactory sensory neurons that reside on the olfactory epithelium in the nasal cavity, which ...
Romana Stark
wiley   +1 more source

EpiClock; biological age measurement from blood DNA methylation using a minimal CpG marker set for high-throughput iPlex mass spectrometry assay for screening in drug development and population health

Experimental Gerontology
Measuring biological aging—the underlying rate of physiological decline—has become increasingly important in predicting disease risk, guiding personalized health strategies, and advancing age-targeted therapeutics.
Hyojung Kim, Ah-Hyun Park, Minjae Kwon, Kyoung Joo Lee, Min-Jeong Kim, Min-Seob Lee   +5 more
doaj   +1 more source