Results 91 to 100 of about 1,113 (145)

Altered miRNA expression network in locus coeruleus of depressed suicide subjects [PDF]

, 2017
Norepinephrine (NE) is produced primarily by neurons in the locus coeruleus (LC). Retrograde and ultrastructural examinations reveal that the core of the LC and its surrounding region receives afferent projections from several brain areas which provide ...
A Kozomara, A Schroeder, A Sequeira, AE Pasquinelli, B Roy, C Nagy, CJ Murray, CW Berridge, DP Bartel, DR Ziegler, EM Valdizan, ER Samuels, F Tretter, G Lugli, G Turecki, GA Ordway, GA Ordway, GN Pandey, GN Pandey, H Sun, H Zhu, HI Im, HJ Caruncho, IS Vlachos, J Gonzalez-Maeso, J Hardin, J Xu, J Zhang, JD Bremner, K Heeringen van, KJ Livak, M Kanehisa, M Kanehisa, M Kanehisa, MA Oquendo, MJ Chandley, MO Poulter, MY Zhu, NR Smalheiser, NR Smalheiser, OV Grinchuk, P Brambilla, P Landgraf, Q Fu, R Bernard, RC Bagot, RC Kessler, SA George, SJ Gosline, SL Foote, T Metsalu, VG Tusher, WP Kloosterman, X Chen, X Ren, Y Altuvia, Y Dwivedi, Y Dwivedi, Y Dwivedi, Y Dwivedi, Y Dwivedi, Y Dwivedi   +61 more
core   +1 more source

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility [PDF]

, 2019
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC)
Agliardi C., Alfredsson L., Amoroso A., An D., Andlauer T. F. M., Baker A., Ban M., Baranzini S. E., Barcellos L. F., Barizzone N., Beecham A. H., Benedetti M. D., Bernardinelli L., Berthele A., Bomfim I. L., Booth D., Bos S. D., Bradshaw E., Brandes A., Buck D., Caillier S. J., Calabresi P., Cavalla P., Celius E. G., Cimpean M., Clarelli F., Comabella M., Comi G., Compston A., Cotsapas C., Cournu-Rebeix I., Cree B. A. C., Cross A., Cusi D., D'Alfonso S., Damotte V., Dardiotis E., Davis M., De Bakker P. W. I., De Jager P. L., Delgado S., Dembele M., Dubois B., Edwards K., Esposito F., Ferre L., Fitzgerald K., Fontaine B., Frohlich I. Y., Galimberti D., Gasperi C., Gomez-Cabrero D., Goris A., Gourraud P. -A., Graetz C., Grummel V., Guaschino C., Guillot-Noel L., Hadjigeorgiou G., Hafler D., Haines J. L., Hakonarson H., Harbo H. F., Hauser S. L., Hawkins C., Hemmer B., Hillert J., Hintzen R., Hoshi M., Hysi P., Isobe N., Ivinson A. J., Jagodic M., James T., Jelcic I., Kalra S., Karpe F., Keenan B., Khadake J., Kimbrough D., Knier B., Kockum I., Konidari I., Korn T., Lachance G., Lage K., Lathi E., Lathrop M., Lee M. H., Leone M. A., Li T., Lill C. M., Linden M., Luessi F., Madireddy L., Mancini N., Manrique C. P., Martin R., Martinelli V., Martinelli-Boneschi F., McCabe C., McCauley J. L., Mescheriakova J., Mitrovic M., Moiola L., Molyneux P., Montalban X., Muhlau M., Neville M., Oksenberg J. R., Olah M., Olsson T., Oturai A., Panteliadis I. -P., Patrick E., Patsopoulos N. A., Pericak-Vance M. A., Pers T. H., Piccio L., Piehl F., Pongratz V., Replogle J., Robbins A., Saarela J., Salvetti M., Santaniello A., Santoro S., Sawcer S., Schaefer C., Sellebjerg F., Shoostari P., Sondergaard H. B., Sorensen P. S., Sorosina M., Sospedra M., Spurkland A., Stewart G., Taylor B., Thorner L. W., Thorpe J., Ullum H., Van Duijn C., Vecchio D., Vlachos I. S., Vukusic S., Weiner H., White C., Winn P., Wong G., Zarzycki O., Zauli A., Zimmer A., Zipp F., Zuccala M.   +153 more
core   +4 more sources

A potassium‐chloride co‐transporter with altered genome architecture functions as a suppressor in glioma

Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.
Abstract Gliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi‐C data, we identified a potassium‐chloride co‐
Hongwei Liu, Zhouyang Pan, Xuelei Lin, Long Chen, Qi Yang, Wei Zhang, Luohuan Dai, Yihao Zhang, Wang Li, Yinhua Chen, Kang Peng, Siyi Wanggou, Feiyue Zeng, Xuejun Li   +13 more
wiley   +1 more source

Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2 [PDF]

, 2019
This is the final version. Available from Hindawi via the DOI in this record.Chloride (Cl-) homeostasis is an essential process involved in neuronal signalling and cell survival.
Tillman, L, Zhang, J
core   +1 more source

Global gene expression profiling in human lung cells exposed to cobalt

BMC Genomics, 2007
Background It has been estimated that more than 1 million workers in the United States are exposed to cobalt. Occupational exposure to 59 Co occurs mainly via inhalation and leads to various lung diseases.
Steinmetz Gerard, Ruat Sylvie, Prat Odette, Berenguer Frederic, Malard Veronique, Quemeneur Eric   +5 more
doaj   +1 more source

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance. [PDF]

, 2016
BackgroundBipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain.AimsWe sought to assess the ...
Bellivier, F., Bergen, S. E., Castelao, E., Chen, C., Chen, C., Cichon, S., Degenhardt, F. A., Dong, Q., Etain, B., Fuller, C. K., Fullerton, J. M., Gordon, S. D., Grigoroiu-Serbanescu, M., Henry, C., Hultman, C. M., Hyde, T. M., Jamain, S., Kahn, J. P., Kleinman, J. E., Kutalik, Z., Landen, M., Leboyer, M., Li, H., Li, M., Li, X., Liu, C., Liu, J., Luo, X. J., Martin, N. G., Mattheisen, M., Medland, S. E., Mitchell, P. B., Montgomery, G. W., Moo, D. S. Consortium, Muhleisen, T. W., Nothen, M. M., Preisig, M., Rietschel, M., Schofield, P. R., Schulze, T. G., Su, B., Swedish Bipolar Study, Group, Weinberger, D. R., Wright, A., Yao, Y. G., Zhang, C., Zhang, W.   +46 more
core   +1 more source

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 [PDF]

, 2009
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes ...
Mesirov, Jill P.
core   +1 more source

The change in methylome entropy as an indicator of epigenetic deregulation caused by stress or malignant transformation [PDF]

, 2017
Koncept entropije prelazi granice teorijske fizike i može se proširiti na teoriju informacije, gdje je poznat kao Shannonova entropija i služi za kvantifikaciju informacijskog sadržaja poruke.
Rožmanić, Carmen
core  

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.There is another ORE record for this publication: http://hdl.handle.net/10871/33406The K+-Cl-co-transporter KCC2 (SLC12A5) tunes the efficacy of ...
Al Awabdh, S, Eugène, E, Gomez-Castro, F, Heubl, M, Kahle, KT, Lévi, S, Moutkine, I, Poncer, JC, Pressey, JC, Renner, M, Russeau, M, Zhang, J   +11 more
core   +5 more sources

Gene expression in the dorsal root ganglion and the cerebrospinal fluid metabolome in polyneuropathy and opioid tolerance in rats

IBRO Neuroscience Reports
First-line pharmacotherapy for peripheral neuropathic pain (NP) of diverse pathophysiology consists of antidepressants and gabapentinoids, but only a minority achieve sufficient analgesia with these drugs.
Fredrik H.G. Ahlström, Hanna Viisanen, Leena Karhinen, Vidya Velagapudi, Kim J. Blomqvist, Tuomas O. Lilius, Pekka V. Rauhala, Eija A. Kalso   +7 more
doaj   +1 more source