Results 111 to 120 of about 1,113 (145)

Additional file 2 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 2. Figure S2 (a) Methylation status of CpG islands in the SLC12A5 gene, with the red box indicating the CpG island selected for experimental purposes. (b) Effects of KCC2 overexpression and knockdown on WNK1 activity in U251 cells.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes

Frontiers in Immunology
IntroductionAlzheimer’s disease (AD) is one of the most prevalent forms of dementia globally and remains an incurable condition that often leads to death.
Wenxu Wang, Wenxu Wang, Jincheng Lu, Jincheng Lu, Ningyun Pan, Ningyun Pan, Huiying Zhang, Jingcen Dai, Jie Li, Cheng Chi, Liumei Zhang, Liang Wang, Mengying Zhang, Mengying Zhang   +13 more
doaj   +1 more source

Additional file 4 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 4.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Additional file 3 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

Supplementary Material 3.Figure S3 (a) Flow cytometry analysis of the effect of IHMT-337 on apoptosis in U87 and U251 cells. (b) TUNEL assay to evaluate the effect of IHMT-337 on apoptosis in U87 and U251 cells. (c) EdU assay assessing the impact of IHMT-337 on cell proliferation in U251 cells.
Zhang, Hongwei, Wang, Zixuan, Qiao, Xiaolong, Peng, Nan, Wu, Jiaxing, Chen, Yinan, Cheng, Chuandong   +6 more
openaire   +1 more source

Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain

Acta Neuropathologica Communications
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in infants and toddlers, with limited treatment options and persistent neurological sequelae.
Alexandra Hochstetler, Ya’el Courtney, Peace Oloko, Benjamin Baskin, Andrew Ding-Su, Tawny Stinson, Elyssa Alber, David Y. Chung, Declan McGuone, Robin Haynes, Maria K. Lehtinen, Beth Costine-Bartell   +11 more
doaj   +1 more source

Mendelian randomisation and colocalisation reveal pleiotropic effects of CD40/SLC12A5 locus on CD40 protein, depression, and immune disease

Abstract Inflammatory pathways are implicated in depression, but the specific immune proteins and causal variants involved remain unclear. This study investigated potential causal relationships between 91 immune-related plasma proteins and depression using generalized summary Mendelian randomisation.
Rachel Laattoe, Elina Hypponen, David Stacey, Sarah Cohen-Woods   +3 more
openaire   +1 more source

The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

Journal of Translational Medicine
Background Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechanistic models emerge as a tool of ...
Marina Esteban-Medina, Carlos Loucera, Kinza Rian, Sheyla Velasco, Lorena Olivares-González, Regina Rodrigo, Joaquin Dopazo, Maria Peña-Chilet   +7 more
doaj   +1 more source

Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma [PDF]

, 2014

core   +1 more source

Solute carrier family 12 potassium-chloride transporter member 5 (SLC12A5; KCC2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Transporters [PDF]

, 2017
,, Alexander, Stephen Ph, Davies, Jamie A, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +10 more
core   +10 more sources