Results 111 to 120 of about 1,526 (158)

Colocalization Reprioritizes the Major Depressive Disorder Druggable Genome: Demotion of the Top TWAS Signal (DRD2) and Nomination of SLC12A5/FURIN/DCC by Direction-Aware, Confirmation-Gated Analysis of 635 GWAS Loci

Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS, direction-aware drug repurposing, and summary-based colocalization to prioritize causal genes and ...
openaire   +1 more source

The Wistar-Kyoto rat as a model relevant to inattentive ADHD: substrain variability and affective comorbidity. [PDF]

Pharmacol Rep
Gaik N, Dzierkacz E, Faron-Górecka A.
europepmc   +1 more source

Immune-Related Mendelian Randomization Signals for Anxiety Disorders Highlight the CD40 Locus on Chromosome 20 (chr20:46118-46130 Mb, GRCh38). [PDF]

Genes (Basel)
Wang L, Duan Y, Sun B, Kang SO, Ye Z, Liu R.   +5 more
europepmc   +1 more source

Gender Medicine and Pharmacology. [PDF]

Biomedicines
Allegra S, Chiara F, De Francia S.
europepmc   +1 more source

Exploring the molecular interface of gene expression dynamics and prostate cancer susceptibility in response to HBCD exposure. [PDF]

Toxicol Res (Camb)
Ni Y, Wang W, Jiang L, Shao Q.
europepmc   +1 more source

Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases. [PDF]

Transl Psychiatry
Zhu Y, Zhao G, Zhang Y, Lu Z, Kang Z, Feng X, Liao Y, Sun J, Yuan R, Yang Y, Guo J, Liu B, Sun Y, Yue W.   +13 more
europepmc   +1 more source

Neurobehavioral Signatures of Epileptogenesis: Molecular Programs, Trait-like Phenotypes, and Translational Biomarkers Beyond Seizures. [PDF]

Int J Mol Sci
Narodova EA.
europepmc   +1 more source

Association between blood pressure traits, hypertension, antihypertensive drugs and calcific aortic valve stenosis: a mendelian randomization study. [PDF]

J Geriatr Cardiol
Lei WH, Zhang JL, Liao YB, Wang Y, Xu F, Zhang YY, Xu Y, Zhou J, Huang FY, Chen M.   +9 more
europepmc   +1 more source

A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma. [PDF]

J Cell Mol Med
Liu H, Pan Z, Lin X, Chen L, Yang Q, Zhang W, Dai L, Zhang Y, Li W, Chen Y, Peng K, Wanggou S, Zeng F, Li X.   +13 more
europepmc   +1 more source

PANA-Surv: A Pathway-Guided Adaptive Neighborhood Augmentation Framework Using KEGG Pathways for Multi-Omics Cancer Prognosis. [PDF]

Genes (Basel)
Cao X, Zhou Y, Dong Y, Zhang X, Mei JP, Li J, Wang Y, Zhuo J, He H, Gu J.   +9 more
europepmc   +1 more source