Results 71 to 80 of about 1,113 (145)
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract INTRODUCTION Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD‐related phosphoprotein in the human brain remains underexplored.
Ana W. Capuano +10 more
wiley +1 more source
Identification of microRNAs influential in glioblastoma cancer stem cells [PDF]
, 2015 1. INTRODUCTION 1.1 BACKGROUND ON GLIOBLASTOMA 1.1.1 EPIDEMIOLOGY Cerebral tumors account for 1-2% of all cancers in Switzerland(1)(2). 58% of primary brain tumors are gliomas (1).
JOVANOVIC, M.
core
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]
, 2017 Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder +3 more
core +2 more sources
Advanced Science, Volume 12, Issue 4, January 27, 2025.Tumors develop resistance to therapeutic agents, unfortunately, efforts to overcome resistance have achieved limited success. m6A RNA modification dysregulation is an emerging mechanism for cancer therapy resistance. This review comprehensively discusses recent studies regarding the contributions of m6A modification and its regulators to cancer therapy
Mohammad Burhan Uddin +2 more
wiley +1 more source
Synaptic proteome changes in a DNA repair deficient Ercc1 mouse model of accelerated aging [PDF]
, 2012 Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here we used Ercc1 mutant mice, which are impaired in multiple DNA repair systems and consequently show accelerated aging and progressive memory deficits, to ...
Hoeijmakers, J.H.J. (Jan) +10 more
core +3 more sources
Human Brain Mapping, Volume 46, Issue 1, January 2025.We discovered 24 novel genes linked to working memory by integrating brain imaging, gene expression, and genetic data, validated in ABCD and UK Biobank. This highlights key pathways, offering new insights into the genetic basis of cognition. ABSTRACT Working memory (WM) plays a crucial role in human cognition.
Xiaoyu Zhao +7 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2011 Mutations in the homeobox transcription factor ARX have been found to be responsible for a wide spectrum of disorders extending from phenotypes with severe neuronal migration defects, such as lissencephaly, to mild forms of intellectual disabilities ...
Gaelle M Friocourt, John G Parnavelas
doaj +1 more source
Modulation of Chloride Homeostasis by Inflammatory Mediators in Dorsal Root Ganglion Neurons [PDF]
, 2008 Background Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl- accumulation in sensory endings establishes the driving force for depolarizing, and even excitatory, Cl ...
Katharina Funk +5 more
core +1 more source
Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons [PDF]
, 2020 KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl-) extruder critical for hyperpolarizing GABA(A) receptor currents.
Delpire, Eric +5 more
core +1 more source
Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex
Advanced Science, Volume 11, Issue 47, December 18, 2024.This study applies spatial transcriptomics and single‐cell RNA sequencing to study molecular heterogeneity of subplate neurons (SPNs) in human fetal brains from gestational week 10 to 25. Human‐specific and extracellular matrices (ECM) genes are found to maintain SPN population. Enriched ECM gene expressions in the frontal lobe suggest a potential role
Xueyu Guo +6 more
wiley +1 more source