Results 71 to 80 of about 1,526 (158)

The Molecular Genetic Investigation of Epilepsy of Infancy with Migrating Focal Seizures [PDF]

, 2018
Epilepsy of infancy with migrating focal seizures (EIMFS) is characterised by the onset of frequent focal seizures in the first 6 months of life, a typical migratory EEG pattern and severe developmental delay.
McTague, Amy
core   +1 more source

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Frontiers in Molecular Neuroscience
IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission.
Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Claudio Rivera, Anastasia Ludwig   +12 more
doaj   +1 more source

Integrated Analysis to Evaluate the Prognostic Value of Signature mRNAs in Glioblastoma Multiforme

Frontiers in Genetics, 2020
BackgroundGliomas are the most common intracranial tumors and are classified as I–IV. Among them, glioblastoma multiforme (GBM) is the most common invasive glioma with a poor prognosis.
Ji’an Yang, Long Wang, Zhou Xu, Liquan Wu, Baohui Liu, Junmin Wang, Daofeng Tian, Xiaoxing Xiong, Qianxue Chen   +8 more
doaj   +1 more source

Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex

Advanced Science, Volume 11, Issue 47, December 18, 2024.
This study applies spatial transcriptomics and single‐cell RNA sequencing to study molecular heterogeneity of subplate neurons (SPNs) in human fetal brains from gestational week 10 to 25. Human‐specific and extracellular matrices (ECM) genes are found to maintain SPN population. Enriched ECM gene expressions in the frontal lobe suggest a potential role
Xueyu Guo, Trevor Lee, Jason Sun, Julianne Sun, Wenjie Cai, Qingwei Yang, Tao Sun   +6 more
wiley   +1 more source

Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs

Open Biology
Frontotemporal lobe abnormalities are linked to neuropsychiatric disorders and cognition, but the role of cellular heterogeneity between temporal lobe (TL) and frontal lobe (FL) in the vulnerability to genetic risk factors remains to be elucidated.
Jiatong Ji, Honglu Chao, Huimei Chen, Jun Liao, Wenqian Shi, Yangfan Ye, Tian Wang, Yongping You, Ning Liu, Jing Ji, Enrico Petretto   +10 more
doaj   +1 more source

Mendelian randomisation and colocalisation reveal pleiotropic effects of the CD40/SLC12A5 locus on CD40 protein, depression, and immune disease

Inflammatory pathways are implicated in depression, but the specific immune proteins and causal variants involved remain unclear. We tested potential causal relationships between 91 immune-related plasma proteins and depression using Generalised Summary ...
David Stacey, Rachel Laattoe, Sarah Cohen-Woods, Elina Hyppönen   +3 more
core   +1 more source

Heatmap of gene expression of neuronal cell markers.

, 2013
Shows the expression profile of neuronal cell markers in GM and WM. There was an expression bias towards GM with the up-regulation of NEFL, GABRA1, SYT1, SLC12A5, SV2B being statistically significant (q ...
Woojin S. Kim (228803), Bei Jun Chen (475737), Michael Janitz (475738), Yoshihiro Kawahara (68375), Glenda M. Halliday (228807), James D. Mills (475735), Tomas Kavanagh (475736)   +6 more
core   +1 more source

ABC Efflux Transporters and Solute Carriers in the Early Developing Brain of a Marsupial Monodelphis domestica (South American Gray Short‐Tailed Opossum)

Journal of Comparative Neurology, Volume 532, Issue 7, July 2024.
We compared transcriptomic profiles and functionality of ABC and SLC transporters in marsupial Monodelphis domestica brain and eutherian rat brain and placenta. Data indicate that despite its extreme immaturity, Monodelphis brain may compensate for a lack of placental protection during early brain development by upregulating protective mechanisms ...
Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Fiona Qiu, Ana C. C. Leandro, Paul D. Callaghan, Joanne E. Curran, John L. VandeBerg, Norman R. Saunders   +8 more
wiley   +1 more source

EpiClock; biological age measurement from blood DNA methylation using a minimal CpG marker set for high-throughput iPlex mass spectrometry assay for screening in drug development and population health

Experimental Gerontology
Measuring biological aging—the underlying rate of physiological decline—has become increasingly important in predicting disease risk, guiding personalized health strategies, and advancing age-targeted therapeutics.
Hyojung Kim, Ah-Hyun Park, Minjae Kwon, Kyoung Joo Lee, Min-Jeong Kim, Min-Seob Lee   +5 more
doaj   +1 more source

Comprehensive analysis of lncRNA‐associated ceRNA network reveals novel potential prognostic regulatory axes in glioblastoma multiforme

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Deciphering the lncRNA‐associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers for GBM by constructing a lncRNA‐miRNA‐mRNA network.
Maryam Bazrgar, Seyed Amir Mirmotalebisohi, Mohsen Ahmadi, Parisa Azimi, Leila Dargahi, Hakimeh Zali, Abolhassan Ahmadiani   +6 more
wiley   +1 more source