Results 101 to 110 of about 20,364 (275)

Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer

Journal of Advanced Research
Breast cancer (BC) is the most common malignancy in women with unfavorite prognosis.Tanshinone IIA (Tan IIA) inhibits BC progression, however, the underlying mechanism remains largely undefined.The cytotoxicity of Tan IIA was assessed by CCK-8 and LDH assays. Ferroptosis was monitored by the level of MDA, Fe2+, lipid ROS and GSH.
Luo, Na, Zhang, KeJing, Li, Xin, Hu, Yu, Guo, Lei   +4 more
openaire   +2 more sources

MiR-93-5p inhibits ovarian cancer through SLC7A11-mediated-ferroptosis

Aim: Ovarian cancer (OC) is the most lethal gynecological malignancy, which seriously affects the prognosis and life quality of female patients. Therefore, new therapeutic targets and treatments are urgently needed.
Hua Liu, Yanqing Wang, Yanxiang Cheng, Chunxia Li, Zitao Wang   +4 more
core   +1 more source

Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

, 2021
Anti-proliferative effect of SLC7A11 knockdown in CAFs and the effect of SLC7A11 inhibition in MiaPaCa-2 PDAC cells and normal human pancreatic ductal epithelial (HPDE) cells.
Jorjina Kasparian (14949258), Jeff Holst (14949216), Estrella Gonzales-Aloy (14949246), Jennifer P. Morton (9143584), Brooke A. Pereira (14949225), Sigrid K. Fey (14942140), Angela Chou (519815), Amber Johns (3988427), Nigel Turner (166154), Anouschka Akerman (14215337), Joshua A. McCarroll (12502138), Andrew D. Campbell (9772366), Yi Fang Guan (14949249), Yordanos F. Setargew (14949264), Anthony J. Gill (14949243), Mert Erkan (54888), Minoti V. Apte (14949252), Cyrille Boyer (1352049), Benjamin J. McLean (14949261), Julia Lee (2002213), Koroush S. Haghighi (14949255), George Sharbeen (14949207), Jessica L. Chitty (14949228), David Goldstein (14949219), Arafath K. Najumudeen (14949231), Paul Timpson (841144), Janet Youkhana (2855546), Stephanie Naim (390408), Phoebe A. Phillips (14949267), Chantal Kopecky (14949210), Thomas R. Cox (14949222), Nelson Russia (14949240), John Kokkinos (14949213), Val Gebski (732415), Owen J. Sansom (14949234), Thomas P. Davis (521458), Rosa Mistica C. Ignacio (3207519), Marina Pajic (132629), Jie Liu (14949237)   +38 more
core   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress [PDF]

Oxidative stress limits metastasis, and amoeboid cancer cells have been identified in a variety of cancers as a subset of metastatic cancer cells characterized by high Rho-ROCK-driven Myosin II activity.
Graziani, Vittoria, Martí Laborda, Rosa Maria, Matias-Guiu, Xavier, 1958-, Barcelo Pérez, Jaume, Tripp, Aurelien, Poulogiannis, George, Das, Dipanwita, Maiques, Oscar, Sanz Moreno, Victoria, Vinaga, Andrea, Crosas Molist, Eva, Sewell, Joanne, Liautard, Manon, James Martin, Joshua Alexander   +13 more
core   +2 more sources

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

, 2020
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age.
Wallace, Leanne, Bentley, Steven R, Pearson, John, Dalrymple-Alford, John, Horvath, Steve, Bentley, Steven R., Henders, Anjali K., Wray, Naomi R., Silburn, Peter A., Gratten, Jacob, Kassam, Irfahan, McRae, Allan F, Silburn, Peter A, Mellick, George D, Chuang, Yu-Hsuan, Kennedy, Martin, Qi, Ting, Pitcher, Toni, Fowdar, Javed, Anderson, Tim, Mellick, George D., McRae, Allan F., Nabais, Marta F., Vallerga, Costanza L, Visscher, Peter M, Wray, Naomi R, Visscher, Peter M., Zhang, Qian, Lewis, Simon J. G., Henders, Anjali K, Halliday, Glenda, Vallerga, Costanza L., Ritz, Beate, Montgomery, Grant, Kwok, John B, Lewis, Simon JG, Nabais, Marta F, Hickie, Ian, Yang, Jian, Kwok, John B., Zhang, Futao   +40 more
core   +1 more source

DataSheet2_Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis.CSV

, 2021
While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging.
Huaqing Li (593541), Qian Chen (18883), Zhiyu Pan (3056349), Hongjian Ding (3163866), Jiajun He (1359126)   +4 more
core   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source