Results 221 to 228 of about 17,501 (228)

Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis

Biochemical and Biophysical Research Communications, 2021
Osteosarcoma is the most common primary orthopedic malignant bone tumor in adolescents. However, the traditional neoadjuvant chemotherapy regimen has reached the bottleneck. TPZ is a hypoxic prodrug that has a powerful anti-tumor effect in the hypoxic microenvironment of tumors.
Yihua Shi, Ming Gong, Zhouming Deng, Huifan Liu, Yiqiang Chang, Zhiqiang Yang, Lin Cai   +6 more
openaire   +2 more sources

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences
Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed.
Chen, Xiong, Hong, Ling, Yingdan, Huang, Hanzhi, Dong, Bangxiang, Xie, Qian, Hao, Xiang, Zhou   +6 more
openaire   +2 more sources

GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression

Biochemical and Biophysical Research Communications, 2020
Ferroptosis is an iron-dependent form of regulated cell death. GDF15 affects various properties of cancer cells, but the role of GDF15 in ferroptosis has not been reported. In the present study, we found that GDF15 knockdown led to decreased expression of SLC7A11, which is a key component of system Xc- and a regulator of ferroptosis, indicating that ...
Liang Chen, Linlin Qiao, Yue Bian, Xiuju Sun   +3 more
openaire   +2 more sources

Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation

Nature Chemical Biology
The mechanism of ferroptosis propagation is still unclear. Here our results indicate that the cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.
Hai-Liang Zhang, Yi-Qing Guo, Shan Liu, Zhi-Peng Ye, Li-Chao Li, Bing-Xin Hu, Zhi-Ling Li, Yu-Hong Chen, Gong-Kan Feng, Hui-Qi Shen, Rong Deng, Xiao-Feng Zhu   +11 more
openaire   +2 more sources

SLC7A11 as a prognostic biomarker for hepatocellular carcinoma.

Journal of Clinical Oncology
e16004 Background: Disulfidptosis has been discovered as a mechanism of cell death mediating by SLC7A11. Nonetheless, little is known about the relationship between SLC7A11 and hepatocellular carcinoma (HCC). Methods: The clinical and follow-up data of 84 consecutive HCC cases who met the inclusion criteria from 2016 to 2019 were retrospectively ...
Yuxi Wang, Xi Li, Ya Zhou, Xiao Meng, Ying Wang, Xiaomei Liu   +5 more
openaire   +1 more source

Solute Carrier Family 7 Member 11 (SLC7A11)

A Target Enabling Package focused on SLC7A11 as it relates to Alzheimer's ...
openaire   +1 more source

Depletion of SLC7A11 Sensitizes Nasopharyngeal Carcinoma Cells to Ionizing Radiation

Protein & Peptide Letters
Background: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy is compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays a role in promoting cancer cell death.
Fan, Yang, Hongxun, Gong, Shiyan, Chen, Jianzhong, Li, Ning, Huang, Maoxin, Wang   +5 more
openaire   +2 more sources

Role of Slc7a11 in Bleomycin-Induced Lung Injury

Lung
Jeffrey D. Ritzenthaler, Edilson Torres-Gonzalez, Yvonne Janssen-Heininger, Walter H. Watson, Jesse Roman   +4 more
openaire   +1 more source