Results 1 to 10 of about 157,081 (164)
Genetic Algorithm-Based Method for Discovering Involutory MDS Matrices
Computational and Mathematical Methods, 2023 In this paper, we present an innovative approach for the discovery of involutory maximum distance separable (MDS) matrices over finite fields F2q, derived from MDS self-dual codes, by employing a technique based on genetic algorithms. The significance of
El Mehdi Bellfkih +4 more
doaj +1 more source
Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm
Frontiers in Aging Neuroscience, 2021 Background: CircRNAs have been found to play a crucial role in the pathological process of various kinds of diseases. However, the role of circRNAs in the formation and rupture of intracranial aneurysm is still unknown.Methods: Differentially expressed ...
Xin Chen +31 more
doaj +1 more source
USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
Open Biology, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Lina Herhaus +11 more
doaj +1 more source
Frontiers in Immunology, 2021 The mechanisms of diabetic retinopathy (DR), are not yet fully understood. We previously demonstrated an upregulation of retinal bone morphogenetic protein-2 (BMP2) in experimental diabetes and in retinas of diabetic human subjects.
Mohamed Al-Shabrawey +20 more
doaj +1 more source
TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
Cells, 2021 TGF-β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-β/Smad signalling pathway have been found to produce disparate effects on neurogenesis.
Lih-Fhung Hiew +3 more
doaj +1 more source
The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1 [PDF]
Open Biology, 2013 The signalling pathways downstream of the transforming growth factor beta (TGFβ) family of cytokines play critical roles in all aspects of cellular homeostasis.
Gopal P. Sapkota
doaj +1 more source
The Journal of Poultry Science, 2022 Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu +5 more
doaj +1 more source
The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats
Open Life Sciences, 2021 The areca nut is one of the most commonly consumed psychoactive substances worldwide, with an estimated consumption by approximately 10% of the world’s population, especially in some regions of South Asia, East Africa, and the tropical Pacific. Arecoline,
Ku Chang-Wen +7 more
doaj +1 more source
Advances on TGF-β/Smad signal pathway in hepatic fibrosis
生物医学转化, 2021 The transforming growth factor-β (TGF-β) signaling pathway plays a vital role in regulating cell processes. As far as the liver is concerned, the TGF-β signaling pathway runs through liver diseases, from theinitial liver cell injury to inflammation ...
Han Daoning, Su Xiulan
doaj +1 more source
All Life, 2022 Osteosarcoma (OS), a common bone malignancy, is highly metastatic and featured by poor prognosis. SUMOylation is deeply involved in tumorigenesis and cancer progression.
Xiangang Jin +5 more
doaj +1 more source