Results 11 to 20 of about 165,371 (351)

Systems theory of Smad signaling [PDF]

IEE Proceedings - Systems Biology, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the ...
Alves, Alves, Barkai, Battogtokh, Brightman, Brown, Brown, Chacko, Chen, Colland, Conery, D.C. Clarke, Derynck, Dong, Fink, Funaba, Fung, Gardner, Hager, Haugh, Hoffmann, Huang, Inman, Inman, Jayaraman, Kawabata, Kholodenko, Kim, Lagna, Lander, Lee, Liu, M.D. Betterton, Massague, Massague, Massague, Nakao, Nakao, Nicolas, Nicolas, Park, Pasche, Pierreux, Poncelet, Remy, Schmierer, Schoeberl, Sedaghat, Shi, Shi, Subramanian, ten Dijke, Tewari, Tian, Tsukazaki, Vilar, von Dassow, Wu, X. Liu, Xu, Xu, Yamada, Zhang, Zi   +63 more
core   +3 more sources

Tissue-specific I-Smad mechanisms revealed by structure-function analysis in <i>Drosophila</i>. [PDF]

Life Sci Alliance
Simoncek AM, Sviridoff SJ, Hays JN, Graichen NJ, Sulkowski MJ.   +4 more
europepmc   +2 more sources

It’s a SMAD/SMAD World [PDF]

Cell, 2015
DPC4/SMAD4 mutations are associated with aggressive pancreatic cancer. In this issue of Cell, Whittle et al. demonstrate that Runx3 expression combined with Dpc4/Smad4 status can predict the metastatic propensity of pancreatic tumors, providing valuable guidance for personalized therapy for patients with pancreatic cancer.
Taniguchi, Cullen, Maitra, Anirban
openaire   +2 more sources

Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Frontiers in Pharmacology, 2018
Background: Liver fibrosis is a complex inflammatory and fibrogenic process, and the progression of fibrosis leads to cirrhosis. The only therapeutic approaches are the removal of injurious stimuli and liver transplantation. Therefore, the development of
Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto   +7 more
doaj   +1 more source

TGF-β Signaling

Biomolecules, 2020
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological embryogenesis and adult tissue homeostasis.
Kalliopi Tzavlaki, Aristidis Moustakas
doaj   +1 more source

The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers

Biomolecules, 2023
Transforming growth factor-β (TGF-β) has attracted attention as a tumor suppressor because of its potent growth-suppressive effect on epithelial cells.
Tasuku Matsuoka, Masakazu Yashiro
doaj   +1 more source

The Epithelial-to-Mesenchymal Transition-Like Process Induced by TGF-β1 Enhances Rubella Virus Binding and Infection in A549 Cells via the Smad Pathway

Microorganisms, 2021
Virus–host cell interactions in rubella virus (RuV) are of great interest in current research in the field, as their mechanism is not yet well understood.
Ngan Thi Kim Pham, Quang Duy Trinh, Kazuhide Takada, Chika Takano, Mari Sasano, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine-Aizawa, Satoshi Hayakawa   +8 more
doaj   +1 more source

Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis

Reproductive Medicine and Biology, 2018
Background Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a
Fumio Otsuka
doaj   +1 more source

Myostatin Increases Smad2 Phosphorylation and Atrogin-1 Expression in Chick Embryonic Myotubes

The Journal of Poultry Science, 2019
Skeletal muscle mass is an important trait in poultry meat production. In mammals, myostatin, a negative regulator of skeletal muscle growth, activates Smad transcription factors and induces the expression of atrogin-1 by regulating the Akt/FOXO pathway.
Takaoki Saneyasu, Kazuhisa Honda, Hiroshi Kamisoyama   +2 more
doaj   +1 more source

ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus [PDF]

Open Biology, 2017
Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through ...
Pengcheng Ma, Biyu Ren, Xiangcai Yang, Bin Sun, Xiaoliang Liu, Qinghua Kong, Chaocui Li, Bingyu Mao   +7 more
doaj   +1 more source