Results 21 to 30 of about 165,371 (351)

Smad transcription factors [PDF]

Genes & Development, 2005
Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Joan, Massagué, Joan, Seoane, David, Wotton   +2 more
openaire   +2 more sources

miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor

Open Medicine, 2023
The activation of hepatic stellate cells (HSCs) is regarded as the primary driving factor of liver fibrosis. miR-192, a miRNA associated with hepatocellular carcinoma and enriched in HSCs, has an undisclosed role in HSC activation and liver fibrosis.
Kang Hui, Luo Jie, Wang Chun, Hong Yinghui, Ye Mingliang, Ding Yang, Zhao Qiu, Chang Ying   +7 more
doaj   +1 more source

Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients

Frontiers in Bioscience-Landmark, 2021
Introduction: Patients with primary biliary cholangitis (PBC) are at increased risk for development of hepatocellular carcinoma (HCC), particularly in the presence of comorbidities such as excessive alcohol consumption.
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma   +14 more
doaj   +1 more source

GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype

Cells, 2020
Macrophages are critical for regulation of inflammatory response during endotoxemia and septic shock. However, the mediators underlying their regulatory function remain obscure.
Lu Wang, Yutian Li, Xiaohong Wang, Peng Wang, Kobina Essandoh, Shunan Cui, Wei Huang, Xingjiang Mu, Zhenling Liu, Yigang Wang, Tianqing Peng, Guo-Chang Fan   +11 more
doaj   +1 more source

It’s a SMAD, SMAD World

JACC: Basic to Translational Science, 2019
[Figure: see text]
openaire   +3 more sources

Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal

Fly, 2017
Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration.
Aiguo Tian, Jin Jiang
doaj   +1 more source

TSG-6 Inhibits the Growth of Keloid Fibroblasts Via Mediating the TGF-β1/Smad Signaling Pathway

Journal of Investigative Surgery, 2021
Background The cytokine TNF-α-stimulated gene-6 (TSG-6) had been verified to have a certain inhibitory effect on the inflammation. During wound healing, fibroblasts increasingly proliferated and deposited collagen fibers, leading to the formation of ...
Xin-Yi Li, Xiao-Juan Weng, Xiao-Jing Li, Xiao-Yu Tian   +3 more
doaj   +1 more source

Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins [PDF]

Open Biology, 2012
Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3.
Elizabeth M. Callery, Chong Yon Park, Xin Xu, Haitao Zhu, James C. Smith, Gerald H. Thomsen   +5 more
doaj   +1 more source

A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment

Biomolecules, 2019
Transforming growth factor (TGF)-β is a secreted multifunctional cytokine that signals via plasma membrane TGF-β type I and type II receptors and intercellular SMAD transcriptional effectors.
Linh Khanh Huynh, Christopher John Hipolito, Peter ten Dijke   +2 more
doaj   +1 more source

Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa

Cells, 2020
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-β1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (CD105)
Tania Aguado, Marta García, Adela García, Gemma Ferrer-Mayorga, Lucía Martínez-Santamaría, Marcela del Río, Luisa-María Botella, José-María Sánchez-Puelles   +7 more
doaj   +1 more source