Results 31 to 40 of about 165,371 (351)
Brazilian Neurosurgery, 2023 Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade ...
Güven Gürsoy +4 more
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Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. [PDF]
PLoS ONE, 2012 The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and proliferation.
Chris Hough, Maria Radu, Jules J E Doré
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Non-coding RNA Research, 2021 One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of ...
Aima Adylova +4 more
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules, 2019 The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego +4 more
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Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]
, 2010 Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Lo, Angela K. F. +4 more
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Journal of Cell Science, 2002 Dimeric ligands of the transforming growth factor β (TGF-β) superfamily bind with high affinity to type II and type I receptor serine/threonine kinases on the cell surface and induce hetero-tetrameric receptor complexes. In such complexes, constitutively auto-phosphorylated type II receptors (
openaire +2 more sources
Phosphatases in SMAD regulation [PDF]
FEBS Letters, 2012 SMAD transcription factors are key mediators of the transforming growth factor‐beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by
Bruce, D.L., Sapkota, G.P.
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Turning off Smads: Identification of a Smad Phosphatase [PDF]
Developmental Cell, 2006 Although the activation of Smad signaling pathways downstream of TGF-beta superfamily ligands by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphatases that turn off Smad activity. Recently in Genes & Development, describe pyruvate dehydrogenase phosphatase as a Smad1 phosphatase that functions in Drosophila
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Contextual Regulation of TGF-β Signaling in Liver Cancer
Cells, 2019 Primary liver cancer is one of the leading causes for cancer-related death worldwide. Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through membrane receptors and intracellular Smad proteins, which enter the nucleus ...
Shuo Tu +4 more
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MdmX inhibits Smad transactivation [PDF]
Oncogene, 2002 Mdm2 overexpression confers a growth promoting activity upon cells primarily by downregulating the p53 tumor suppressor protein. Nevertheless, Mdm2 deregulation has also been implicated in inhibiting TGF-beta growth repression in a p53 independent manner.
Kadakia, Madhavi +3 more
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