Results 41 to 50 of about 165,371 (351)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Deep learning for de-convolution of Smad2 versus Smad3 binding sites

BMC Genomics, 2022
Background The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets ...
Jeremy W.K. Ng, Esther H.Q. Ong, Lisa Tucker-Kellogg, Greg Tucker-Kellogg   +3 more
doaj   +1 more source

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Frontiers in Molecular Biosciences, 2021
Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts.
Ming-Li Zou, Ming-Li Zou, Zhong-Hua Chen, Ying-Ying Teng, Si-Yu Liu, Si-Yu Liu, Yuan Jia, Yuan Jia, Kai-Wen Zhang, Kai-Wen Zhang, Zi-Li Sun, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Yi Feng, Xia Li, Rui-Sheng Xu, Feng-Lai Yuan   +17 more
doaj   +1 more source

A Folk Tale of a Butterfly [PDF]

, 2009
This folk tale describes how a butterfly and worm respect one anotherThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad Village
Bkra shis bzang po
core  

SMADs Stimulate miRNA Processing [PDF]

Molecular Cell, 2010
MicroRNAs (miRNAs) are potent regulators of gene expression. Consequently, miRNA expression is tightly regulated itself. In this issue, Hata and coworkers provide mechanistic insights into how SMAD proteins regulated the biogenesis of a specific subset of human miRNAs.
Treiber, T., Meister, G.
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IL1B induced Smad 7 negatively regulates gastrin expression. [PDF]

PLoS ONE, 2011
BACKGROUND: Helicobacter pylori elicited IL1B is one of the various modulators responsible for perturbation of acid secretion in gut. We have earlier reported that IL1B activated NFkB downregulates gastrin, a major modulator of acid secretion.
Dipanjana Datta De, Sumana Bhattacharjya, Meenakshi Maitra, Arindam Datta, Abhijit Choudhury, G K Dhali, Susanta Roychoudhury   +6 more
doaj   +1 more source

A Folk Tale of a Poor Man [PDF]

, 2009
Bstan 'dzin tells a folk tale in which a poor man outsmarts a rich manThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad ...
Bkra shis bzang po
core  

Posttranslational Regulation of Smads [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of gene expression responses, which are extensively regulated at multiple levels and vary depending on the physiological context. The formation, activation, and destruction of two major functional complexes in the TGF-β signaling pathway (i.e., the TGF-β receptor ...
Pinglong, Xu, Xia, Lin, Xin-Hua, Feng
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source