Small interfering RNA (siRNA)-based targeting breast cancer therapy [PDF]
Discover OncologyBreast cancer (BC) poses a substantial impact on the global health landscape, thereby demanding the creation of novel therapeutic approaches aimed at enhancing patient outcomes.
Amin Talebi +8 more
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Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview [PDF]
PharmaceuticsIntroduction: Gene therapy using siRNA is a current area of research in oncology. Although siRNA formulations have not yet been approved for cancer therapy, numerous studies have demonstrated their therapeutic potential for tumor remission. Objective: To
Liliana Aranda-Lara +7 more
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Small interfering RNA: From designing to therapeutic in cancer [PDF]
Journal of Genetic Engineering and BiotechnologyCancer has become a significant public health concern worldwide. It is a group of diseases, often resulting from the dysregulation of multiple cellular pathways involved in differentiation, cell proliferation, cell cycle regulation, and DNA repair. These
Jyoti Singh +3 more
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Small interfering RNA effect on lipoprotein(a): a systematic review [PDF]
The Egyptian Heart JournalBackground This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Omar Almaadawy +11 more
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siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [PDF]
IET Systems BiologySmall interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Yang Zhang +8 more
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Human Homeobox TGIFLX Regulates CDX1, CDX2, and OCT1 Genes Expression in Colorectal Cancer Cell Lines [PDF]
Middle East Journal of Cancer, 2022 Background: Homeodomain transcriptional regulatory proteins, which are encoded by Homeobox (HOX) genes, play critical roles in both normal development and carcinogenesis.
Soroosh Shahryarhesami +3 more
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Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy
International Journal of Nanomedicine, 2012 Evelina Miele,1,* Gian Paolo Spinelli,2,* Ermanno Miele,3 Enzo Di Fabrizio,3,6 Elisabetta Ferretti,4 Silverio Tomao,2 Alberto Gulino,1,5 1Department of Molecular Medicine, 2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University ...
Miele E +6 more
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Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia [PDF]
Endocrinology and Metabolism, 2021 Patients with familial hypercholesterolemia (FH) are at high or very high risk for cardiovascular disease. Those with heterozygous FH (HeFH) often do not reach low-density lipoprotein cholesterol (LDL-C) targets with statin and ezetimibe therapy, and ...
Brian Tomlinson +3 more
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Small interfering RNA; toward a new antiviral therapy [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2022 With the ability of viruses to mutate and introduce a high rate of diversity and continuous resistance to drug development, unique solutions are needed. RNA interference (RNAi) pathway as a natural defense mechanism mediated by plants, invertebrates, and
Engy Aziza
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Iron oxide nanoparticles and derivatives for biomedical imaging and application in cancer diagnosis and siRNA therapy [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Yigit, MV +2 more
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