Results 41 to 50 of about 1,407,145 (245)
Bioinformatics approach to processing data from high-throughput sequencing of small RNA molecules
Кардиоваскулярная терапия и профилактикаHigh-throughput sequencing of small ribonucleic acid (RNA) molecules is widely used to search for markers of various diseases, as well as to study the regulation of gene expression.
A. A. Zharikova +3 more
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Frontiers in Molecular Biosciences, 2022 Regulator of chromatin condensation 1 (RCC1) is the major guanine nucleotide exchange factor of RAN GTPase, which plays a key role in various biological processes such as cell cycle and DNA damage repair. Small nucleolar RNA host gene 3 (SNHG3) and small
Kai Hu +4 more
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
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Small RNA modifications in Alzheimer's disease
Neurobiology of Disease, 2020 BackgroundWhile significant advances have been made in uncovering the aetiology of Alzheimer's disease and related dementias at the genetic level, molecular events at the epigenetic level remain largely undefined.
Xudong Zhang +7 more
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A novel method to purify small RNAs from human tissues for methylation analysis by LC-MS/MS
Frontiers in Molecular Biosciences, 2022 Methylation modification of small RNAs, including miRNA, piRNA, and tsRNA, is critical for small RNA biogenesis and biological function. Methylation of individual small RNA can be defined by liquid chromatography-coupled with mass spectrometry (LC-MS/MS).
Rong Yang +7 more
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PLoS Genetics, 2008 For several decades, only a limited number of noncoding RNAs, such as ribosomal and transfer RNA, have been studied in any depth. In recent years, additional species of noncoding RNAs have increasingly been discovered. Of these, small RNA species attract particular interest because of their essential roles in processes such as RNA silencing and ...
Hideya Kawaji, Yoshihide Hayashizaki
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
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Open Life SciencesRafflesiaceae is a family of endangered plants whose members are solely parasitic to the tropical grape vine Tetrastigma (Vitaceae). Currently, the genetics of their crosstalk with the host remains unexplored.
Wicaksono Adhityo +5 more
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An Expanded Landscape of Unusually Short RNAs in 11 Samples from Six Eukaryotic Organisms
Non-Coding RNA, 2022 Small RNA sequencing (sRNA-Seq) approaches unveiled sequences derived from longer non-coding RNAs, such as transfer RNA (tRNA) and ribosomal RNA (rRNA) fragments, known as tRFs and rRFs, respectively.
Marine Lambert +6 more
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The impact of small RNAs [PDF]
EMBO reports, 2006 Our understanding of the RNA‐mediated gene‐regulatory pathway, known as RNA interference (RNAi), has come a long way since its discovery in the early 1990s. At that time, all knowledge of RNA‐mediated silencing was based on one phenomenon: the loss of a non‐lethal phenotype after the introduction of exogenous RNA into the affected organism. Since then,
Obernosterer, G. +3 more
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