Peripheral SNCA+ cells as a poor prognostic factor for nivolumab therapy in advanced gastric cancer [PDF]
Discover OncologyBackground We previously demonstrated that immune cells expressing α-synuclein (SNCA) are dramatically increased in peripheral blood of patients with gastric cancer (GC), but rarely in healthy donors, and that blocking SNCA is significantly effective ...
Chie Kudo-Saito +14 more
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Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1 [PDF]
Cell ReportsSummary: The protein α-synuclein, encoded by SNCA, accumulates in Parkinson’s disease (PD) and other synucleinopathies for reasons that remain unclear. Here, we investigated whether SNCA is regulated in vivo by the RNA-binding protein PUM1.
Maximilian Cabaj +23 more
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Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice [PDF]
Frontiers in NeuroscienceHuman SNCA, which encodes a-synuclein protein (SNCA), was the first gene linked to familial Parkinson’s disease (PD). Since the discovery of the genetic link of SNCA to Parkinson’s nearly three decades ago, many studies have investigated the normal ...
MegAnne Casey +4 more
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Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology [PDF]
Molecular NeurodegenerationThe autophagy-lysosomal pathway is crucial for maintaining homeostasis and survival of neurons, hence defects in this system have been associated with neurodegeneration, including Parkinson's disease (PD).
Denise Balta +17 more
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Assessment of Mitochondrial Gene Activity in Dopaminergic Neuron Cultures Derived from Induced Pluripotent Stem Cells Obtained from Parkinson's Disease Patients [PDF]
Анналы клинической и экспериментальной неврологии, 2023 Introduction. Induced pluripotent stem cells (iPSCs) culturing allows modelling of neurodegenerative diseases in vitro and discovering its early biomarkers.
Anna S. Vetchinova +3 more
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Exploration of Neuroprotective Therapy, 2023 Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)].
Bianca Vlcek +5 more
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Open Biology, 2023 Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan +4 more
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SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma
BMC Cancer, 2022 Background The SNCA gene is a critical gene in Parkinson’s disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains unclear.
Xiuao Zhang, Zhengcun Wu, Kaili Ma
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Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. [PDF]
PLoS ONE, 2009 Genetic variability across the SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis.
Colton Linnertz +8 more
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Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. [PDF]
PLoS ONE, 2015 Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons of the substantia nigra. The hallmark of PD is the appearance of neuronal protein aggregations known as Lewy bodies and Lewy neurites, of which α ...
Warunee Dansithong +4 more
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