Results 11 to 20 of about 12,300 (184)

Neuronal SNCA transcription during Lewy body formation

Acta Neuropathologica Communications, 2023
Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs   +8 more
doaj   +3 more sources

Prognostic significance of SNCA and its methylation in bladder cancer

BMC Cancer, 2022
Background The epidemiological investigation of different cancer types in the global population has reported a decreased risk of bladder cancer (BLCA) in Parkinson’s diseases (PD).
Zhengcun Wu, Chengxing Xia, Chao Zhang, Delin Yang, Kaili Ma   +4 more
doaj   +3 more sources

Methylglyoxal Affects Dopamine Homeostasis in SH-SY5Y Cells Through the Modulation of miR-190a and miR-214. [PDF]

FASEB J
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Croce A, Mirra P, Pignalosa FC, Zatterale F, Prevenzano I, Conza D, Ulianich L, Miele C, Beguinot F, Fiory F.   +9 more
europepmc   +2 more sources

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation [PDF]

Acta Naturae, 2020
Neurodegeneration in Parkinsons disease is characterized by the accumulation of alpha-synuclein, aprotein encoded by theSNCAgene, in neurons. In addition to mutations, many polymorphisms have been identified in this gene, and one of theseis a dinucleotide microsatellite:SNCA-Rep1.The mechanisms by which specific configurations ofSNCA-Rep1 may ...
Iakovenko, E. V., Abramycheva, N. Yu., Fedotova, E. Yu., Illarioshkin, S. N.   +3 more
openaire   +2 more sources

SNCA 3′ UTR Genetic Variants in Patients with Parkinson’s Disease [PDF]

Biomolecules, 2021
The SNCA (Synuclein Alpha) gene represents a major risk gene for Parkinson’s disease (PD) and SNCA polymorphisms have been associated with the common sporadic form of PD. Numerous Genome-Wide Association Studies showed strong signals located in the SNCA 3′ UTR (untranslated region) region indicating that variants in 3′ UTRs of PD-associated genes could
Antonela Blažeković, Kristina Gotovac Jerčić, Fran Borovečki   +2 more
openaire   +5 more sources

CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. [PDF]

PLoS ONE, 2010
BACKGROUND: Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson's disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic ...
Lumine Matsumoto, Hiroshi Takuma, Akira Tamaoka, Hiroshi Kurisaki, Hidetoshi Date, Shoji Tsuji, Atsushi Iwata   +6 more
doaj   +1 more source

Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils. [PDF]

Autophagy
Parkinson disease (PD) and other α-synucleinopathies are characterized by the intracellular aggregates of SNCA/α-synuclein (synuclein, alpha) thought to spread via cell-to-cell transmission. To understand the contributions of various brain cells to the spreading of SNCA pathology, we examined the metabolism of SNCA aggregates in neuronal and glial ...
Karim MR, Tiegs E, Gasparini E, Schlichte R, Vermilyea SC, Lee MK.   +5 more
europepmc   +2 more sources

DNA methylation in Parkinson disease

Анналы клинической и экспериментальной неврологии, 2020
Parkinson disease (PD) is one of the most widespread neurodegenerative diseases in the elderly. It causes motor impairment and the development of non-motor symptoms, which reduce the quality of life and gradually lead to patient disability.
Elena V. Yakovenko, Ekaterina Yu. Fedotova, Sergey N. Illarioshkin   +2 more
doaj   +1 more source

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

Cells, 2020
Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk
Chien-Tai Hong, Kai-Yun Chen, Weu Wang, Jing-Yuan Chiu, Dean Wu, Tsu-Yi Chao, Chaur-Jong Hu, Kai-Yin David Chau, Oluwaseun Adebayo Bamodu   +8 more
doaj   +1 more source

Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region [PDF]

Open Biology, 2016
Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one ...
Pelagia Koukouraki, Epaminondas Doxakis   +1 more
doaj   +1 more source