Results 131 to 140 of about 6,543 (175)

Age-related changes in calcium ion influx and efflux capacity of human dermal fibroblasts. [PDF]

Cell Commun Signal
Han SJ, Kwon S, Park HJ, Kim KS.
europepmc   +1 more source

A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults. [PDF]

PLoS One
Shawer H, Cheng CW, Hemmings KE, Aldawsari AM, Revilla-González G, Stocco F, Shi J, Beech DJ, Bailey MA.   +8 more
europepmc   +1 more source

Neuronal SOCE: Myth or Reality? [PDF]

Trends in Cell Biology, 2016
Store-operated Ca2+ entry (SOCE) is the primary Ca2+ influx pathway in non-excitable cells. Long thought to be absent in nerve cells, neuronal SOCE is gaining popularity. We argue here that the evidence for SOCE in neurons remains contentious, mostly because SOCE imaging assays are inadequate in these cells.
Marc Fivaz
exaly   +3 more sources

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The multifaceted role of SOCE in central synapses

Cell Calcium, 2021
Store-operated calcium entry (SOCE) is a mechanism for calcium influx through the plasma membrane in response to release of free calcium from the endoplasmic reticulum. Two recent studies revealed how SOCE regulates the exocytosis of neurotransmitter vesicles at central synapses.
Vincenzo Roncace, Filip De Souza Polli, Anton Maximov   +2 more
exaly   +3 more sources

SOCE in neurons: Signaling or just refilling?

Biochimica Et Biophysica Acta - Molecular Cell Research, 2015
In this review we describe the present knowledge about store operated Ca²⁺ entry (SOCE) in neurons and the proteins involved in this process: STIM, as well as Orai and TRP channels. We address the issue of whether SOCE is used only to refill Ca²⁺ in the ER or whether Ca²⁺ that enters the neuronal cell during SOCE also performs signaling functions.
Jacek Kuźnicki, Lukasz Majewski
exaly   +3 more sources

TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces [PDF]

Cell Calcium, 2017
Store-operated calcium entry (SOCE) is a ubiquitous Ca2+ entry pathway that is activated in response to depletion of ER-Ca2+ stores and critically controls the regulation of physiological functions in miscellaneous cell types. The transient receptor potential canonical 1 (TRPC1) is the first member of the TRPC channel subfamily to be identified as a ...
Lorena Brito De Souza, Indu Ambudkar, Hwei Ling Ong   +2 more
exaly   +3 more sources

Native SOCE complexes: Small but mighty?

Cell Calcium, 2021
Our current understanding of the molecular mechanisms underlying activation of store-operated Ca2+ entry (SOCE) relies in large part on studies that modulate the expression of STIM1 and Orai1. Shen et al. present the first detailed study to address the dynamics and stoichiometry of endogenous STIM1 and Orai1.
Raphael Courjaret, Khaled Machaca
openaire   +2 more sources

The Role of Mitochondria in the Activation/Maintenance of SOCE

2011
Mitochondria modify cellular Ca2+ transport processes and, in turn, almost every Ca2+ signaling event has a notable effect on mitochondrial function. This kind of reciprocal interplay between Ca2+ handling and mitochondria is especially prominent during store-operated Ca2+ entry (SOCE).
András Spät, Gergö Szanda
  +4 more sources

TRICking SOCE into altered oscillations

Cell Calcium, 2020
Defective ER/SR-cytosol Ca2+ cycling is associated with increased ER stress, pathological heart conditions and muscular defects. Within the SR, ryanodine receptor 2 (RyR2) is required for excitation/contraction coupling. Ca2+ release from the SR is counterbalanced by K+ influx through trimeric intracellular cation (TRIC) channels to maintain ER/SR ...
openaire   +2 more sources