Results 141 to 150 of about 6,543 (175)
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Too much of a good thing: The case of SOCE in cellular apoptosis
Cell Calcium, 2023Intracellular calcium (Ca2+) is an essential second messenger in eukaryotic cells regulating numerous cellular functions such as contraction, secretion, immunity, growth, and metabolism. Ca2+ signaling is also a key signal transducer in the intrinsic apoptosis pathway. The store-operated Ca2+ entry pathway (SOCE) is ubiquitously expressed in eukaryotic
Mohamed Trebak
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TRPM7 activation potentiates SOCE in enamel cells but requires ORAI [PDF]
Cell Calcium, 2020 Calcium (Ca2+) release-activated Ca2+ (CRAC) channels mediated by STIM1/2 and ORAI (ORAI1-3) proteins form the dominant store-operated Ca2+ entry (SOCE) pathway in a wide variety of cells. Among these, the enamel-forming cells known as ameloblasts rely on CRAC channel function to enable Ca2+ influx, which is important for enamel mineralization.
Rodrigo Lacruz +2 more
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Arriving at the next level of complexity in IP3R and SOCE signaling
Cell Calcium, 2023The endoplasmic reticulum (ER) has long been recognized as the master regulator of cellular Ca2+ signaling. In this context, IP3R channels may be envisioned as this conductor's baton, which enables virtuous orchestration of cellular Ca2+ signaling tunes.
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2017
The junctions between the endoplasmic reticulum and the plasma membrane are essential platforms for the activation of store-operated Ca2+ influx. These junctions have specific dimensions and are nonuniformly distributed in polarized cells. The mechanisms involved in the formation of the junctions are currently undergoing vigorous investigation, and ...
Hayley, Dingsdale +4 more
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The junctions between the endoplasmic reticulum and the plasma membrane are essential platforms for the activation of store-operated Ca2+ influx. These junctions have specific dimensions and are nonuniformly distributed in polarized cells. The mechanisms involved in the formation of the junctions are currently undergoing vigorous investigation, and ...
Hayley, Dingsdale +4 more
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SOCE, mitochondria, and inflammation
Science Signaling, 2019Store-operated calcium entry regulates mitochondrial function to support pathogenic T H 17 cells and promote inflammation.
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New Aspects of the Contribution of ER to SOCE Regulation
2011Apart from amplifying the cytosolic Ca2+ signals generated by Ca2+ mobilization from the endoplasmic reticulum (ER), capacitative calcium entry (CCE) is essential for quick refilling of the ER, which is necessary for repeating Ca2+ signals. SERCA is the third element of CCE.
Hayley Dingsdale +3 more
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SOCE and STIM1 signaling in the heart: Timing and location matter
Cell Calcium, 2019Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in STIM1 and Orai1, the two SOCE ...
Paul Rosenberg +2 more
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Activation of STIM1/Orai1‑mediated SOCE in sepsis‑induced myocardial depression
Molecular Medicine Reports, 2022Unbalanced Ca2+ homeostasis serves an essential role in the occurrence and development of septic myocardial injury. However, the mechanism of Ca2+ homeostasis in septic myocardial depression is poorly understood due to the complexity of Ca2+ transporters in excitable cells.
Jingjing, Ye +8 more
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Role of SOCE architects STIM and Orai proteins in Cell Death
Cell Calcium, 2018Calcium (Ca2+) signaling plays a critical role in regulating plethora of cellular functions including cell survival, proliferation and migration. The perturbations in cellular Ca2+ homeostasis can lead to cell death either by activating autophagic pathways or through induction of apoptosis.
Jyoti, Tanwar, Rajender K, Motiani
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Modification of glycan chains as a mechanism to regulate SOCE (P1156)
The Journal of Immunology, 2013Abstract T cell receptor mediated activation requires the influx of calcium from the extracellular medium. Here, the endoplasmic reticulum (ER) Ca2+ sensor STIM1 reports the decrease in luminal [Ca2+] caused by IP3 receptor activity, clusters and directly binds and activates Orai1 channels, providing Ca2+ influx (store-operated, SOCE ...
Tatiana Kilch +4 more
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