Results 151 to 160 of about 6,543 (175)
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Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
2017Among the Ca2+ entry mechanisms in platelets, store-operated Ca2+ entry (SOCE) plays a prominent role as it is necessary to achieve full activation of platelet functions and replenish intracellular Ca2+ stores. In platelets, as in other non-excitable cells, SOCE has been reported to involve the activation of plasma membrane channels by the ER Ca2 ...
Jose J, Lopez +2 more
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Role of calreticulin in store-operated Ca entry (SOCE)
Qatar Foundation Annual Research Forum Volume 2013 Issue 1, 2013Title: Role of Calreticulin in Store-operated Ca entry (SOCE) Authors: Satanay Hubrack, Awab Ibrahim, Hamid Massaeli, Nasrin Mesaeli, Khaled Machaca. Abstract: Calreticulin is a pervasive protein that is mainly found within the ER. It has been linked to many cellular functions including Ca2+ storage and signaling along with protein folding. Here we use
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Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
2017Many cellular functions of the vascular endothelium are regulated by fine-tuned global and local, microdomain-confined changes of cytosolic free Ca2+ ([Ca2+]i). Vasoactive agonist-induced stimulation of vascular endothelial cells (VECs) typically induces Ca2+ release through IP3 receptor Ca2+ release channels embedded in the membrane of the endoplasmic
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Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
2017TRPC channels have been suggested as potential candidates mediating store-operated Ca2+ entry (SOCE) in cardiomyocytes. There is increasing evidence that the TRPC isoforms TRPC1 and TRPC4 might fulfill the function as SOCs, in concert with or in parallel to the key players of SOCE, Orai1, and STIM1. Several other isoforms, e.g., TRPC3, TRPC6, and TRPC7,
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ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells
International Journal of Molecular Sciences, 2020Tullio Pozzan +2 more
exaly
The SOCE Machinery: An Unbalanced Knowledge between Left and Right Ventricular Pathophysiology
Cells, 2022Jessica Sabourin +2 more
exaly
STIM1 Controls the Focal Adhesion Dynamics and Cell Migration by Regulating SOCE in Osteosarcoma
International Journal of Molecular Sciences, 2022Shih-Chuan Hsiao +2 more
exaly
Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts
Current Pharmaceutical Biotechnology, 2023exaly