Total wash elimination for solid phase peptide synthesis [PDF]
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
doaj +2 more sources
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
María Lumbierres +5 more
openalex +6 more sources
Practical Protocols for Solid-Phase Peptide Synthesis 4.0 [PDF]
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
doaj +2 more sources
Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides [PDF]
Pharmaceutics, 2023 In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred method to obtain peptides is solid-phase peptide synthesis (SPPS), which does not respect the principles of green chemistry due to the large number of ...
Giovanni Vivenzio +5 more
doaj +2 more sources
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Angewandte Chemie, 2004 Solid-phase synthesis of lipidated ...
Goran Kragol +3 more
openalex +7 more sources
Safety-Catch Linkers for Solid-Phase Peptide Synthesis [PDF]
MoleculesSolid-phase peptide synthesis (SPPS) is the preferred strategy for synthesizing most peptides for research purposes and on a multi-kilogram scale. One key to the success of SPPS is the continual evolution and improvement of the original method proposed ...
Sikabwe Noki +2 more
doaj +2 more sources
Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis [PDF]
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj +2 more sources
Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency [PDF]
Ultrasonics SonochemistryThe integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted Solid-Phase Peptide Synthesis (SUS-SPPS) method.
Salvatore Mottola +8 more
doaj +2 more sources
A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis [PDF]
ChemistryOpen, 2021 A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups.
Hongpeng Yang +8 more
doaj +2 more sources
Solid Phase Peptide Synthesis on Chitosan Thin Films. [PDF]
Biomacromolecules, 2022 Katan T +6 more
europepmc +3 more sources