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Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients [PDF]

Pharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah, Cecilia Succhielli, Isha Saraf, Amrit Paudel   +3 more
doaj   +2 more sources

Investigation of Stabilized Amorphous Solid Dispersions to Improve Oral Olaparib Absorption [PDF]

Pharmaceutics
In this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer characterized as a BCS class IV drug with low solubility and low ...
Taehan Yun, Sumin Lee, Seowan Yun, Daeyeong Cho, Kyuho Bang, Kyeongsoo Kim   +5 more
doaj   +2 more sources

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]

Advanced Pharmaceutical Bulletin, 2020
A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade, Jyoti Narayan Yadav   +1 more
doaj   +1 more source

The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution

Carbohydrate Polymer Technologies and Applications, 2021
The purpose of this study was to enhance quercetin (Que) dissolution by preparing its ternary amorphous solid dispersions. The ternary amorphous solid dispersions were prepared by solvent evaporation method using hydroxypropylmethylcellulose acetate ...
Yiru Wang, Wenrong Qin, Qi Liang, Feng Zhou, Chengyun Yan, Yueyi Deng   +5 more
doaj   +1 more source

Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami, Hadi Valizadeh, Ziba Islambulchilar, Parvin Zakeri-Milani   +3 more
doaj   +1 more source

Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

Pharmaceutics, 2023
Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha, Nattakanwadee Khumpirapang, Vimon Tantishaiyakul, Siriporn Okonogi   +3 more
doaj   +1 more source

Abstract 10 — Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through Solid Dispersion Formulation

Journal of Clinical Rheumatology and Immunology, 2023
Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA). However, KETO belongs to the BCS class-II category, characterized by poor water solubility, resulting in less dissolution capability leading
Pankajkumar Yadav
doaj   +1 more source

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Pharmaceutics, 2020
Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions.
Thao T. D. Tran, Phuong H. L. Tran
doaj   +1 more source

Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier

British Journal of Pharmacy, 2023
The aim of this study was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic carrier. These binary solid dispersions were prepared at varying drug loadings using the
Adebisi O Adeola
doaj   +1 more source

Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations

Asian Journal of Pharmaceutical Sciences, 2018
Dissolution molecular mechanism of solid dispersions still remains unclear despite thousands of reports about this technique. The aim of current research was to investigate the molecular dissolution mechanism of solid dispersions by molecular dynamics ...
TengIan Chan, Defang Ouyang
doaj   +1 more source