Results 11 to 20 of about 25,328 (266)

The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000 [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.
Jafar Akbari, Majd Saeedi, Katayoun Morteza-Semnani, Hamid Reza Kelidari, Farshad Sadegh Moghanlou, Gity Zareh, Sohrab Rostamkolaei   +6 more
doaj   +1 more source

Enhancing Dissolution of Ibuprofen via Solid Dispersion Using Hydrophilic Carrier and Fast Dissolving Sugars

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2014
In this study, solid dispersion using hydrophilic carriers (polyethylene glycols) and fast dissolving sugars (sorbitol and lactose) has been employed to enhance dissolution and hence the bioavailability of ibuprofen.
Wedad Kamal Ali, Methaq Hamad Sabar, Athmar Dhahir Habeeb, Zainb Hassan Mahdi   +3 more
doaj   +1 more source

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones

Asian Journal of Pharmaceutical Sciences, 2017
Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones.
Xifeng Zhai, Chunguang Li, George Binh Lenon, Charlie C.L. Xue, Weize Li   +4 more
doaj   +1 more source

Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®

Molecules, 2015
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Jinwen Liu, Meijuan Zou, Hongyu Piao, Yi Liu, Bo Tang, Ying Gao, Ning Ma, Gang Cheng   +7 more
doaj   +1 more source

EFFECT OF SOLID DISPERSIONS ON THE SOLUBILITY OF METRONIDAZOLE

Фармация и фармакология (Пятигорск), 2021
The aim of the work is to study the effect of solid dispersions using polyethylene glycols of various molecular weights on the solubility of metronidazole in water. Metronidazole is an antimicrobial and antiprotozoal drug.
I. I. Krasnyuk (Jr.), S. R. Naryshkin, I. I. Krasnyuk, A. V. Belyatskaya, O. I. Stepanova, I. S. Bobrov, V. G. Yankova, J. V. Rau, A. N. Vorobiev   +8 more
doaj   +1 more source

Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet.
Mayank Chaturvedi, Manish Kumar, Kamla Pathak, Shailendra Bhatt, Vipin Saini   +4 more
openaire   +3 more sources

Current Trends on Solid Dispersions: Past, Present, and Future

Advances in Pharmacological and Pharmaceutical Sciences, 2022
Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs.
Ruba Malkawi, Walla I. Malkawi, Yahia Al-Mahmoud, Jawad Tawalbeh   +3 more
doaj   +1 more source

Polyelectrolyte Complex Based Interfacial Drug Delivery System with Controlled Loading and Improved Release Performance for Bone Therapeutics

Nanomaterials, 2016
An improved interfacial drug delivery system (DDS) based on polyelectrolyte complex (PEC) coatings with controlled drug loading and improved release performance was elaborated.
David Vehlow, Romy Schmidt, Annett Gebert, Maximilian Siebert, Katrin Susanne Lips, Martin Müller   +5 more
doaj   +1 more source

Development and characterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents

Asian Journal of Pharmaceutical Sciences, 2017
Solid dispersions of nifedipine (NDP), a poorly water-soluble drug, and amino methacrylate copolymer (AMCP) with aid of adsorbent, that is, fumed silica, talcum, calcium carbonate, titanium dioxide, and mesoporous silica from rice husks (SRH), were ...
Yotsanan Weerapol, Sontaya Limmatvapirat, Jurairat Nunthanid, Srisuda Konthong, Supakij Suttiruengwong, Pornsak Sriamornsak   +5 more
doaj   +1 more source

Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

Pharmaceutics, 2020
This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive
Verônica da Silva Oliveira, Amanda Silva de Almeida, Ingrid da Silva Albuquerque, Fernanda Ílary Costa Duarte, Bárbara Cristina Silva Holanda Queiroz, Attilio Converti, Ádley Antonini Neves de Lima   +6 more
doaj   +1 more source