Results 21 to 30 of about 128,995 (308)

EFFECT OF SOLID DISPERSIONS ON THE SOLUBILITY OF METRONIDAZOLE

Фармация и фармакология (Пятигорск), 2021
The aim of the work is to study the effect of solid dispersions using polyethylene glycols of various molecular weights on the solubility of metronidazole in water. Metronidazole is an antimicrobial and antiprotozoal drug.
I. I. Krasnyuk (Jr.), S. R. Naryshkin, I. I. Krasnyuk, A. V. Belyatskaya, O. I. Stepanova, I. S. Bobrov, V. G. Yankova, J. V. Rau, A. N. Vorobiev   +8 more
doaj   +1 more source

Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet.
Mayank Chaturvedi, Manish Kumar, Kamla Pathak, Shailendra Bhatt, Vipin Saini   +4 more
openaire   +3 more sources

Development and characterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents

Asian Journal of Pharmaceutical Sciences, 2017
Solid dispersions of nifedipine (NDP), a poorly water-soluble drug, and amino methacrylate copolymer (AMCP) with aid of adsorbent, that is, fumed silica, talcum, calcium carbonate, titanium dioxide, and mesoporous silica from rice husks (SRH), were ...
Yotsanan Weerapol, Sontaya Limmatvapirat, Jurairat Nunthanid, Srisuda Konthong, Supakij Suttiruengwong, Pornsak Sriamornsak   +5 more
doaj   +1 more source

Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography [PDF]

, 2016
Purpose: This study investigated the effect of drug-excipient miscibility on the heterogeneity and spatial distribution of phase separation in pharmaceutical solid dispersions at a micron-scale using two novel and complementary characterization ...
Alhijjaj, Muqdad, Belton, Peter, Qi, Sheng, Reading, Mike, Yassin, Samy, Zeitler, J. Axel   +5 more
core   +1 more source

Polyelectrolyte Complex Based Interfacial Drug Delivery System with Controlled Loading and Improved Release Performance for Bone Therapeutics

Nanomaterials, 2016
An improved interfacial drug delivery system (DDS) based on polyelectrolyte complex (PEC) coatings with controlled drug loading and improved release performance was elaborated.
David Vehlow, Romy Schmidt, Annett Gebert, Maximilian Siebert, Katrin Susanne Lips, Martin Müller   +5 more
doaj   +1 more source

Structural anisotropy of directionally dried colloids [PDF]

, 2014
Aqueous colloidal dispersions of silica particles become anisotropic when they are dried through evaporation. This anisotropy is generated by a uniaxial strain of the liquid dispersions as they are compressed by the flow of water toward a solidification ...
Bacchin P., Bernard Cabane, François Boulogne, Frédérique Giorgiutti-Dauphiné, Joaquim Li, Lucas Goehring, Ludovic Pauchard, Michael Sztucki, Ralf Schweins, Robert Botet, Routh A. F.   +10 more
core   +4 more sources

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

Pharmaceutics, 2019
The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon® 12 PF and Kollidon® VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray ...
Tereza Školáková, Michaela Slámová, Andrea Školáková, Alena Kadeřábková, Jan Patera, Petr Zámostný   +5 more
doaj   +1 more source

Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

Pharmaceutics, 2020
This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive
Verônica da Silva Oliveira, Amanda Silva de Almeida, Ingrid da Silva Albuquerque, Fernanda Ílary Costa Duarte, Bárbara Cristina Silva Holanda Queiroz, Attilio Converti, Ádley Antonini Neves de Lima   +6 more
doaj   +1 more source

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

Pharmaceutics, 2021
The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers.
Basanth Babu Eedara, Dinesh Nyavanandi, Sagar Narala, Prabhakar Reddy Veerareddy, Suresh Bandari   +4 more
doaj   +1 more source

Improved dissolution of Kaempferia parviflora extract for oral administration by preparing solid dispersion via solvent evaporation

Asian Journal of Pharmaceutical Sciences, 2017
Kaempferia parviflora, a plant in the family Zingiberaceae, has been used in Thai traditional medicines for treating hypertension and promoting longevity with good health and well-being.
Yotsanan Weerapol, Sukannika Tubtimsri, Chaweewan Jansakul, Pornsak Sriamornsak   +3 more
doaj   +1 more source