Results 31 to 40 of about 25,328 (266)

Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

Pharmaceutics, 2019
In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound.
Fei Han, Wei Zhang, Ying Wang, Ziyue Xi, Lu Chen, Sanming Li, Lu Xu   +6 more
doaj   +1 more source

Screening of Ketoprofen-Poloxamer and Ketoprofen-Eudragit solid dispersions for improved physicochemical characteristics and dissolution profile

Brazilian Journal of Pharmaceutical Sciences, 2020
The aim of the present study was to enhance the dissolution rate of an NSAID drug Ketoprofen by formulating it into solid dispersions with water soluble carrier Poloxamer 188 and Eudragit S 100. The solid dispersions of Ketoprofen with Poloxamer 188 were
Ravi Yashwant Savardekar, Amol Shantinath Sherikar   +1 more
doaj   +1 more source

Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and Dissolution Enhancer in Solid Dispersion

Pharmaceuticals, 2022
Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac ...
Mobina Manzoor, Syed Atif Raza, Mulazim Hussain Asim, Nadeem Irfan Bukhari, Shumaila Arshad, Uzma Zafar   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enhancement of dissolution of atorvastatin through preparation of polymeric solid dispersions using supercritical fluid technology

Research in Pharmaceutical Sciences, 2020
Background and purpose: This study aimed at preparation of solid dispersions in order to enhance dissolution of poorly water-soluble atorvastatin using supercritical CO2 technology.
Bashar Altaani, Rana Obaidat, Walaa Malkawi   +2 more
doaj   +1 more source

Development and Characterization of Solid Dispersion for Dissolution Improvement of Furosemide by Cogrinding Method [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. Methods: Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using ...
Mohammad Reza Siahi-Shadbad, Saeed Ghanbarzadeh, Mohammad Barzegar-Jalali, Hadi Valizadeh, Alireza Taherpoor, Ghobad Mohammadi, Azim Barzegar-Jalali, Khosro Adibkia   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Manufacturing Different Types of Solid Dispersions of BCS Class IV Polyphenol (Daidzein) by Spray Drying: Formulation and Bioavailability

Pharmaceutics, 2019
Daidzein (DZ) is a polyphenolic compound belonging to Biopharmaceutical Classification System class IV, which shows that it may have limited therapeutic effects due to its low solubility and poor bioavailability. This study aimed to obtain high-purity DZ
Gean Pier Panizzon, Fernanda Giacomini Bueno, Tânia Ueda-Nakamura, Celso Vataru Nakamura, Benedito Prado Dias Filho   +4 more
doaj   +1 more source

Characterization of olanzapine-solid dispersions.

Iranian journal of pharmaceutical research : IJPR, 2011
To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization.
Krishnamoorthy, Venkateskumar, Nagalingam, Arunkumar, Ranjan Prasad, Verma Priya, Parameshwaran, Siva, George, Neema, Kaliyan, Punitha   +5 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source