Total wash elimination for solid phase peptide synthesis [PDF]
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides [PDF]
Pharmaceutics, 2023 In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred method to obtain peptides is solid-phase peptide synthesis (SPPS), which does not respect the principles of green chemistry due to the large number of ...
Giovanni Vivenzio +5 more
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Practical Protocols for Solid-Phase Peptide Synthesis 4.0 [PDF]
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
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Safety-Catch Linkers for Solid-Phase Peptide Synthesis [PDF]
MoleculesSolid-phase peptide synthesis (SPPS) is the preferred strategy for synthesizing most peptides for research purposes and on a multi-kilogram scale. One key to the success of SPPS is the continual evolution and improvement of the original method proposed ...
Sikabwe Noki +2 more
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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis [PDF]
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
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Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency [PDF]
Ultrasonics SonochemistryThe integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted Solid-Phase Peptide Synthesis (SUS-SPPS) method.
Salvatore Mottola +8 more
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A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis [PDF]
ChemistryOpen, 2021 A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups.
Hongpeng Yang +8 more
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SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION [PDF]
Journal of IMAB, 2011 The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin.
Tamara Paypanova +2 more
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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis [PDF]
Nature Communications, 2019 Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and ...
Alexandra Schischko +5 more
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Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]
Molecules, 2018 An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela +2 more
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