Total wash elimination for solid phase peptide synthesis [PDF]
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Advances in Fmoc solid-phase peptide synthesis. [PDF]
J Pept Sci, 2016 Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad
Behrendt R, White P, Offer J.
europepmc +5 more sources
Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis [PDF]
Nature Communications, 2019 Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and ...
Alexandra Schischko +5 more
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Automated solid-phase peptide synthesis to obtain therapeutic peptides [PDF]
Beilstein Journal of Organic Chemistry, 2014 The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde +2 more
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Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar +3 more
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Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy. [PDF]
Molecules, 2021 Peptide synthesis is an area with a wide field of application, from biomedicine to nanotechnology, that offers the option of simultaneously synthesizing a large number of sequences for the purpose of preliminary screening, which is a powerful tool ...
Guzmán F +8 more
europepmc +2 more sources
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
María Lumbierres +5 more
openalex +6 more sources
Practical Protocols for Solid-Phase Peptide Synthesis 4.0 [PDF]
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
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Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides [PDF]
Pharmaceutics, 2023 In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred method to obtain peptides is solid-phase peptide synthesis (SPPS), which does not respect the principles of green chemistry due to the large number of ...
Giovanni Vivenzio +5 more
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Evaluation of greener solvents for solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 Polar aprotic solvents such as N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), N,N’-dimethylacetamide (DMAc) and chlorinated solvent such dichloromethane (DCM) are the most widely used solvents for Fmoc solid-phase peptide synthesis (SPPS ...
Katarzyna Wegner +4 more
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