Peptides, solid-phase synthesis and characterization: Tailor-made methodologies
Electronic Journal of Biotechnology, 2023 Background: Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the diverse requirements, regarding the number, quantity and quality of peptides.
Fanny Guzmán +6 more
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Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?
Beilstein Journal of Organic Chemistry, 2017 While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS).
Ophélie Maurin +5 more
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Promotion of the collagen triple helix in a hydrophobic environment [PDF]
, 2019 In contrast to many other water-soluble peptide arrangements, the formation of a triple helix in collagen proceeds inside out: polar glycyl residues form the interior, whereas nonpolar prolyl side chains constitute the exterior.
Budisa, Nediljko, Kubyshkin, Vladimir
core +1 more source
Solid Phase Formylation of N-Terminus Peptides
Molecules, 2016 Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification of histones. The addition of a formyl group (CHO) to the N-terminal end of a peptide chain generates biologically active
Anna Lucia Tornesello +2 more
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A new method of N to C sequential ligation using thioacid capture ligation and native chemical ligation [PDF]
Royal Society Open Science, 2018 Sequential peptide ligation strategy becomes more and more important in large protein or long peptides chemical synthesis due to the limited peptide/protein size obtained by solid phase synthesis of individual peptides or even one-step peptide ligation ...
Wen Hou +3 more
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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer [PDF]
, 2016 The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution.We report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid ...
Clayden, Jonathan +5 more
core +4 more sources
Solid-Phase Synthesis of Oxetane Modified Peptides [PDF]
Organic Letters, 2017 Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C═O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, then integrated into peptide chains by conventional Fmoc SPPS.
Jonathan D. Beadle +5 more
openaire +3 more sources
Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries. [PDF]
, 2008 Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has
Greaves, John +3 more
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Synthesis of a Cyclooctapeptide, Cyclopurpuracin, and Evaluation of Its Antimicrobial Activity
Molecules, 2023 Cyclopurpuracin is a cyclooctapeptide isolated from the methanol extract of Annona purpurea seeds with a sequence of cyclo-Gly-Phe-Ile-Gly-Ser-Pro-Val-Pro.
Rani Maharani +9 more
doaj +1 more source