Results 11 to 20 of about 24,357,552 (149)

Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System

Biomedicines, 2023
Lansoprazole (LZP) is used to treat acid-related gastrointestinal disorders; however, its low aqueous solubility limits its oral absorption. Black seed oil (BSO) has gastroprotective effects, making it a promising addition to gastric treatment regimens ...
Abdelrahman Y. Sherif, Ahmad Abdul-Wahhab Shahba   +1 more
doaj   +2 more sources

A novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for improved stability and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol [PDF]

Drug Delivery, 2017
To develop a novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for a water-insoluble oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) with improved stability and oral bioavailability, numerous S-SNEDDS were prepared with ...
Kyeong Soo Kim, Eun Su Yang, Dong Shik Kim, Dong Wuk Kim, Hye Hyun Yoo, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Jun-Pil Jee, Jong Oh Kim, Sung Giu Jin, Han Gon Choi   +11 more
doaj   +2 more sources

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe

International Journal of Nanomedicine, 2015
Rehmana Rashid,1 Dong Wuk Kim,1 Abid Mehmood Yousaf,1 Omer Mustapha,1 Fakhar ud Din,1 Jong Hyuck Park,1 Chul Soon Yong,2 Yu-Kyoung Oh,3 Yu Seok Youn,4 Jong Oh Kim,2 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology,
Rashid R, Kim DW, Yousaf AM, Mustapha O, Din FU, Park JH, Yong CS, Oh YK, Youn YS, Kim JO, Choi HG   +10 more
doaj   +1 more source

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. [PDF]

, 2022
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder
Jen-Chang Yang (16939231), Dinesh Kumar Chellappan (3622100), Piyush Kumar Gupta (14423543), Kamal Dua (9903691), Sachin Kumar Singh (8460930), Abhishek Kumar Sharma (17249839), Niraj Kumar Jha (12758798), Chetna Hemrajani (17249845), Alaa A A Aljabali (17249707), Charul Rathore (17249842), Ram Prakash Dwivedi (17249848), Gaurav Gupta (316879), Murtaza Tambuwala (17168338), Poonam Negi (17249815)   +13 more
core   +13 more sources

Self-Nanoemulsifying System Loaded with Sildenafil Citrate and Incorporated within Oral Lyophilized Flash Tablets: Preparation, Optimization, and In Vivo Evaluation

Pharmaceutics, 2020
Sildenafil citrate is a drug used throughout the world primarily to treat erectile dysfunction. Several problems with the commercially available product decrease its efficacy, such as limited solubility, delayed onset of action, and low bioavailability ...
Khaled M. Hosny, Nabil A. Alhakamy, Maeen A. Almodhwahi, Mallesh Kurakula, Alshaimaa M. Almehmady, Samar S. Elgebaly   +5 more
doaj   +2 more sources

Development and Evaluation of Paclitaxel‐Loaded Self‐Nanoemulsifying Drug Delivery System for Enhanced Cancer Therapy: A Promising Alternative to Cremophor EL–Based Formulation [PDF]

IET Nanobiotechnol
Background and Purpose Paclitaxel’s clinical use is limited by poor aqueous solubility and Cremophor EL–related toxicity in commercial formulations. This study aimed to develop a self‐nanoemulsifying drug delivery system (SNEDDS) to improve paclitaxel solubility, bioavailability, and anticancer efficacy.
Almehmady A, Alahmadi A, Hakami A, Ali E, Kalantan A, Aljagthmi A, Ahmed T.   +6 more
europepmc   +2 more sources

3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In Vitro Characterization

Pharmaceutics, 2021
The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. The current investigation aims to explore 3D printing for the design and development of a nanomedicine-based oral ...
Mohammed S. Algahtani, Abdul Aleem Mohammed, Javed Ahmad, M. M. Abdullah, Ehab Saleh   +4 more
doaj   +1 more source

NANOTECHNOLOGY APPROACH-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) [PDF]

, 2023
This review article aims to develop nanotechnology in novel drug delivery systems using self-nano emulsifying drug delivery systems (SNEDDS). This Article was selected using a database with Prism Guideline diagrams.
MUTIAH, ROIHATUL, YUWONO, MOCHAMMAD, HENDRADI, ESTI, ANNISA, RAHMI   +3 more
core   +3 more sources

Development and optimization of Ropinirole loaded self-nanoemulsifying tablets

Future Journal of Pharmaceutical Sciences, 2023
Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral ...
Krunal Detholia, Amrutha Mohandas, Umang Varia, Mukesh Jadeja, Hitesh Katariya   +4 more
doaj   +1 more source

Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility

International Journal of Nanomedicine, 2011
Yang Lei1,2, Yi Lu2, Jianping Qi2, Sufang Nie1, Fuqiang Hu3, Weisan Pan1, Wei Wu21School of Pharmacy, Shenyang Pharmaceutical University, Shenyang; 2School of Pharmacy, Fudan University, Shanghai; 3School of Pharmacy, Zhejiang University, Hangzhou ...
Lei Y, Lu Y, Qi J, Nie S, Hu F, Pan W, Wu W   +6 more
doaj   +1 more source